Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 389875..390599 | Replicon | chromosome |
Accession | NZ_CP086253 | ||
Organism | Pectobacterium aquaticum strain A212-S19-A16 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | DMB82_RS01775 | Protein ID | WP_102117149.1 |
Coordinates | 389875..390186 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | DMB82_RS01780 | Protein ID | WP_039539501.1 |
Coordinates | 390183..390599 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DMB82_RS01755 (DMB82_0001765) | 385028..385762 | + | 735 | WP_116163586.1 | type I-E CRISPR-associated protein Cas5/CasD | - |
DMB82_RS01760 (DMB82_0001770) | 385762..386409 | + | 648 | WP_116163587.1 | type I-E CRISPR-associated protein Cas6/Cse3/CasE | - |
DMB82_RS01765 (DMB82_0001775) | 386437..387354 | + | 918 | WP_012822191.1 | type I-E CRISPR-associated endonuclease Cas1e | - |
DMB82_RS01770 (DMB82_0001780) | 387355..387648 | + | 294 | WP_102117148.1 | type I-E CRISPR-associated endoribonuclease Cas2e | - |
DMB82_RS01775 (DMB82_0001785) | 389875..390186 | + | 312 | WP_102117149.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
DMB82_RS01780 (DMB82_0001790) | 390183..390599 | + | 417 | WP_039539501.1 | helix-turn-helix domain-containing protein | Antitoxin |
DMB82_RS01785 (DMB82_0001795) | 390826..391284 | + | 459 | WP_102117151.1 | hypothetical protein | - |
DMB82_RS01790 (DMB82_0001800) | 391545..391991 | + | 447 | WP_102117152.1 | YhbP family protein | - |
DMB82_RS01795 (DMB82_0001805) | 392096..392749 | + | 654 | WP_102117153.1 | hypothetical protein | - |
DMB82_RS01800 (DMB82_0001810) | 392761..393225 | - | 465 | WP_102117154.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
DMB82_RS01805 (DMB82_0001815) | 393307..395445 | - | 2139 | WP_102117155.1 | anaerobic ribonucleoside-triphosphate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12478.34 Da Isoelectric Point: 9.8530
>T222826 WP_102117149.1 NZ_CP086253:389875-390186 [Pectobacterium aquaticum]
MHVISRAPFDTATTQFPNQAAVLDDLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE
MHVISRAPFDTATTQFPNQAAVLDDLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE
Download Length: 312 bp
>T222826 NZ_CP118143:c6350383-6350090 [Pseudomonas chlororaphis]
ATGAACGAACCGCTTTTCGACTATGACCCCGCCACGGCCCTGCGCGACCCGCAGGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCATTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA
ATGAACGAACCGCTTTTCGACTATGACCCCGCCACGGCCCTGCGCGACCCGCAGGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCATTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15392.62 Da Isoelectric Point: 4.5581
>AT222826 WP_039539501.1 NZ_CP086253:390183-390599 [Pectobacterium aquaticum]
MMYADAIKAANNLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFVD
MMYADAIKAANNLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFVD
Download Length: 417 bp
>AT222826 NZ_CP118143:c6350679-6350380 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCGCCGGTGGGCGAAGGCGTCAGTGAGCTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCGCCGGTGGGCGAAGGCGTCAGTGAGCTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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