Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 389875..390599 Replicon chromosome
Accession NZ_CP086253
Organism Pectobacterium aquaticum strain A212-S19-A16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DMB82_RS01775 Protein ID WP_102117149.1
Coordinates 389875..390186 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DMB82_RS01780 Protein ID WP_039539501.1
Coordinates 390183..390599 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB82_RS01755 (DMB82_0001765) 385028..385762 + 735 WP_116163586.1 type I-E CRISPR-associated protein Cas5/CasD -
DMB82_RS01760 (DMB82_0001770) 385762..386409 + 648 WP_116163587.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -
DMB82_RS01765 (DMB82_0001775) 386437..387354 + 918 WP_012822191.1 type I-E CRISPR-associated endonuclease Cas1e -
DMB82_RS01770 (DMB82_0001780) 387355..387648 + 294 WP_102117148.1 type I-E CRISPR-associated endoribonuclease Cas2e -
DMB82_RS01775 (DMB82_0001785) 389875..390186 + 312 WP_102117149.1 type II toxin-antitoxin system HigB family toxin Toxin
DMB82_RS01780 (DMB82_0001790) 390183..390599 + 417 WP_039539501.1 helix-turn-helix domain-containing protein Antitoxin
DMB82_RS01785 (DMB82_0001795) 390826..391284 + 459 WP_102117151.1 hypothetical protein -
DMB82_RS01790 (DMB82_0001800) 391545..391991 + 447 WP_102117152.1 YhbP family protein -
DMB82_RS01795 (DMB82_0001805) 392096..392749 + 654 WP_102117153.1 hypothetical protein -
DMB82_RS01800 (DMB82_0001810) 392761..393225 - 465 WP_102117154.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DMB82_RS01805 (DMB82_0001815) 393307..395445 - 2139 WP_102117155.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(4-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12478.34 Da        Isoelectric Point: 9.8530

>T222826 WP_102117149.1 NZ_CP086253:389875-390186 [Pectobacterium aquaticum]
MHVISRAPFDTATTQFPNQAAVLDDLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE

Download         Length: 312 bp

>T222826 NZ_CP118143:c6350383-6350090 [Pseudomonas chlororaphis]
ATGAACGAACCGCTTTTCGACTATGACCCCGCCACGGCCCTGCGCGACCCGCAGGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCATTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15392.62 Da        Isoelectric Point: 4.5581

>AT222826 WP_039539501.1 NZ_CP086253:390183-390599 [Pectobacterium aquaticum]
MMYADAIKAANNLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFVD

Download         Length: 417 bp

>AT222826 NZ_CP118143:c6350679-6350380 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGTCTTGCCGGGGACGTGTCGCCGGTGGGCGAAGGCGTCAGTGAGCTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References