Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1948305..1948807 | Replicon | chromosome |
| Accession | NZ_CP086220 | ||
| Organism | Escherichia coli strain 779 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LMB17_RS09765 | Protein ID | WP_000767829.1 |
| Coordinates | 1948305..1948559 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LMB17_RS09770 | Protein ID | WP_001259255.1 |
| Coordinates | 1948556..1948807 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMB17_RS09735 (1943320) | 1943320..1943547 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| LMB17_RS09740 (1943561) | 1943561..1944619 | - | 1059 | WP_023568741.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LMB17_RS09745 (1944798) | 1944798..1946156 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| LMB17_RS09750 (1946146) | 1946146..1946208 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LMB17_RS09755 (1946423) | 1946423..1947352 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| LMB17_RS09760 (1947398) | 1947398..1948222 | - | 825 | WP_000754763.1 | SDR family oxidoreductase | - |
| LMB17_RS09765 (1948305) | 1948305..1948559 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LMB17_RS09770 (1948556) | 1948556..1948807 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LMB17_RS09775 (1949089) | 1949089..1949139 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| LMB17_RS09780 (1949285) | 1949285..1950184 | + | 900 | WP_061093169.1 | ATP phosphoribosyltransferase | - |
| LMB17_RS09785 (1950190) | 1950190..1951494 | + | 1305 | WP_001515511.1 | histidinol dehydrogenase | - |
| LMB17_RS09790 (1951491) | 1951491..1952561 | + | 1071 | WP_000108943.1 | histidinol-phosphate transaminase | - |
| LMB17_RS09795 (1952561) | 1952561..1953628 | + | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T222802 WP_000767829.1 NZ_CP086220:c1948559-1948305 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T222802 NZ_CP118140:c4692040-4691759 [Pseudomonas chlororaphis]
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTCCCGGCCGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AACTGCGCACGGCGGGTTACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGTCATTGCCGTGGGCAAG
CGAGAGCGGGGGAGTGTCTATCAGCAAGCCAGCAAGCGTTAG
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTCCCGGCCGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AACTGCGCACGGCGGGTTACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGTCATTGCCGTGGGCAAG
CGAGAGCGGGGGAGTGTCTATCAGCAAGCCAGCAAGCGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT222802 WP_001259255.1 NZ_CP086220:c1948807-1948556 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT222802 NZ_CP118140:c4692278-4692030 [Pseudomonas chlororaphis]
ATGACCCATGTCCTTCTGTCCAACGTCGTTGCGAGCATTTCCGAGCTCAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGCGGTTCCTCCGTGGCCATCCTCAATCGCAACGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGTCTGGAAGATATGGAGCTGCTCGCCTTGTGCCGTGAACGAGAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACTTATGA
ATGACCCATGTCCTTCTGTCCAACGTCGTTGCGAGCATTTCCGAGCTCAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGCGGTTCCTCCGTGGCCATCCTCAATCGCAACGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGTCTGGAAGATATGGAGCTGCTCGCCTTGTGCCGTGAACGAGAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|