Detailed information of TA system TA222770

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2427050..2427234
• Replicon: chromosome
• Accession: NZ_CP086215
• Organism: Staphylococcus aureus strain Patient 14 Isolate 02

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: LLZ98_RS11980
• Protein ID: WP_000482652.1
• Coordinates: 2427050..2427157 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2427174..2427234 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLZ98_RS11955	2422412..2422885	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
LLZ98_RS11960	2423008..2424219	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
LLZ98_RS11965	2424401..2425060	-	660	WP_000831298.1	membrane protein	-
LLZ98_RS11970	2425120..2426262	-	1143	WP_001176863.1	glycerate kinase	-
LLZ98_RS11975	2426530..2426916	+	387	WP_000779360.1	flippase GtxA	-
LLZ98_RS11980	2427050..2427157	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2427174..2427234	-	61	-	-	Antitoxin
LLZ98_RS11985	2427860..2429623	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
LLZ98_RS11990	2429648..2431381	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
LLZ98_RS11995	2431648..2431779	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T222770 WP_000482652.1 NZ_CP086215:2427050-2427157 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T222770 NZ_CP118136:c6413496-6413203 [Pseudomonas chlororaphis]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGTCCCTGCGTGACCCGCAGGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGTGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGATATGACGGCGCGGGTGCATGGGGCGTCTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT222770 NZ_CP086215:c2427234-2427174 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin