Detailed information of TA system TA222765

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 505605..506184
• Replicon: chromosome
• Accession: NZ_CP086215
• Organism: Staphylococcus aureus strain Patient 14 Isolate 02

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: LLZ98_RS02745
• Protein ID: WP_001025401.1
• Coordinates: 505605..505850 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	505819..506184 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLZ98_RS02695 (501854)	501854..502468	+	615	WP_000191466.1	hypothetical protein	-
LLZ98_RS02700 (502465)	502465..502611	-	147	WP_001795334.1	hypothetical protein	-
LLZ98_RS02705 (502648)	502648..502830	-	183	WP_000705240.1	hypothetical protein	-
LLZ98_RS02710 (502901)	502901..503587	-	687	WP_000177667.1	XRE family transcriptional regulator	-
LLZ98_RS02715 (503784)	503784..503996	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
LLZ98_RS02720 (504044)	504044..504487	+	444	WP_000435357.1	hypothetical protein	-
LLZ98_RS02725 (504502)	504502..504651	+	150	WP_000771849.1	hypothetical protein	-
LLZ98_RS02730 (504692)	504692..504904	-	213	WP_000362644.1	hypothetical protein	-
LLZ98_RS02735 (504974)	504974..505171	+	198	WP_001148860.1	hypothetical protein	-
LLZ98_RS02740 (505158)	505158..505538	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
LLZ98_RS02745 (505605)	505605..505850	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
LLZ98_RS02750 (505819)	505819..506184	-	366	WP_001128433.1	hypothetical protein	Antitoxin
LLZ98_RS02755 (506239)	506239..506454	+	216	WP_001097552.1	hypothetical protein	-
LLZ98_RS02760 (506479)	506479..506742	+	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
LLZ98_RS02765 (506755)	506755..506916	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
LLZ98_RS02770 (506995)	506995..507318	+	324	WP_000174998.1	hypothetical protein	-
LLZ98_RS02775 (507333)	507333..507695	+	363	WP_000985972.1	hypothetical protein	-
LLZ98_RS02780 (507692)	507692..508858	+	1167	WP_000762530.1	DUF2800 domain-containing protein	-
LLZ98_RS02785 (508884)	508884..509441	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T222765 WP_001025401.1 NZ_CP086215:505605-505850 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T222765 NZ_CP118136:433257-433538 [Pseudomonas chlororaphis]
ATGACTTATAAGCTCCAGTTTCTGCCTTCGGCGCGCAAGGAATGGGACAAGCTCGGTCATACCCTGCGCGAGCAATTCAA
GAAGAAGCTGGCCGAGCGCCTGGAAATGCCGCGGGTGCCCGCGGACGCCCTTCACGGTATGGCGGACTGCTACAAGATCA
AGCTCAAGGCCTCTGGCTATCGCCTGGTTTACCAAGTGATCGAGGATCAGGTCGTGGTTTCGGTGGTGGCCGTGGGCAAA
CGTGAACGCAGTGCCGTGTATGAGCGGGCACGAAAGCGCTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT222765 NZ_CP086215:c506184-505819 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin