222747

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1655153..1655757 Replicon chromosome
Accession NZ_CP086206
Organism Pseudomonas sp. HN8-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LJX92_RS07490 Protein ID WP_057022036.1
Coordinates 1655443..1655757 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJX92_RS07485 Protein ID WP_003189536.1
Coordinates 1655153..1655440 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJX92_RS07450 (LJX92_07460) 1650417..1651175 + 759 WP_228309512.1 MBL fold metallo-hydrolase -
LJX92_RS07455 (LJX92_07465) 1651203..1651916 + 714 WP_005786030.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LJX92_RS07465 (LJX92_07475) 1652185..1652478 - 294 WP_103733512.1 type II toxin-antitoxin system RelE/ParE family toxin -
LJX92_RS07470 (LJX92_07480) 1652468..1652707 - 240 WP_014717442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LJX92_RS07475 (LJX92_07485) 1653359..1653613 + 255 WP_032877263.1 hypothetical protein -
LJX92_RS07480 (LJX92_07490) 1653687..1654913 - 1227 WP_032877262.1 MFS transporter -
LJX92_RS07485 (LJX92_07495) 1655153..1655440 - 288 WP_003189536.1 NadS family protein Antitoxin
LJX92_RS07490 (LJX92_07500) 1655443..1655757 - 315 WP_057022036.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJX92_RS07495 (LJX92_07505) 1655863..1656804 - 942 WP_216090883.1 LysR family transcriptional regulator -
LJX92_RS07500 (LJX92_07510) 1656962..1658278 + 1317 WP_228309513.1 MFS transporter -
LJX92_RS07505 (LJX92_07515) 1658290..1659522 + 1233 WP_228309514.1 Zn-dependent hydrolase -
LJX92_RS07510 (LJX92_07520) 1659657..1660694 + 1038 WP_228309515.1 histone deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11656.44 Da        Isoelectric Point: 9.8054

>T222747 WP_057022036.1 NZ_CP086206:c1655757-1655443 [Pseudomonas sp. HN8-3]
MIFIETSVFTRRVKELIDEDAYTALQNVLVVNPSAGDVIEGTGGVRKIRVAAKGHGKRGGARVIYYHFVSASQIVLLMIY
PKNEQQDLTADERKSLKAAIEHWR

Download         Length: 315 bp

>T222747 NZ_CP118106:2786602-2786952 [Paenibacillus urinalis]
TTGATCGTTAAACGCGGCGACGTTTTTTTTGCGGATCTTTCACCCGTTGTCGGTTCCGAGCAAGGGGGAGTCAGACCGGT
GCTTGTGATCCAGAATGATATTGGCAACCGTTTCAGTCCTACTTGTATCGTTGCGGCCATCACGGCTCAGATTCAGAAGG
CGAAGCTGCCGACCCACGTGGAAATTGATGCAGAACTGCACGGTTTTGATCGGGATTCTGTTGTGTTGCTCGAACAGATT
AGAACGATTGACAAACAGCGTCTGACTGACAAGATTACGCATTTAGATGATGATACGATGAAGCTTGTGGGTGAAGCTCT
ACAGATCAGTCTGGGATTAATTGATTTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10828.41 Da        Isoelectric Point: 7.3219

>AT222747 WP_003189536.1 NZ_CP086206:c1655440-1655153 [Pseudomonas sp. HN8-3]
MSRFFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp

>AT222747 NZ_CP118106:2786317-2786598 [Paenibacillus urinalis]
TTGACCAATGTACAGAACACCAAACGGATTATGATTAGTTTGCCGGATCATCTCTTACAGGAAGTAGATGGTATTGTAGC
AATGGAGAATTCGAACCGCAGTGAATTCATCAGGCAAGCCATGAAGCTGTACTTAAACGAACGGAAGAAGCGTTATATCC
GGGAGTCAATGCAGCGAGGCTACATGGAAATGGCCAAGATTAATTTGACCATGGCTTCTGAAGCTTTTCACGCGGAGGAT
GATGCAGACAGCACTCTGGGCCGCTTAGTGAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References