Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2531940..2532598 Replicon chromosome
Accession NZ_CP086203
Organism Morganella morganii strain MMAS2018

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LLY23_RS12650 Protein ID WP_064483784.1
Coordinates 2532245..2532598 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LLY23_RS12645 Protein ID WP_064483783.1
Coordinates 2531940..2532242 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY23_RS12605 (LLY23_12625) 2528305..2529000 - 696 WP_004240015.1 MgtC family protein -
LLY23_RS12610 (LLY23_12630) 2529351..2529545 - 195 WP_015422621.1 protein DsrB -
LLY23_RS12615 (LLY23_12635) 2529649..2529861 - 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
LLY23_RS12620 (LLY23_12640) 2530322..2530831 + 510 WP_004240013.1 YlaC family protein -
LLY23_RS12645 (LLY23_12665) 2531940..2532242 - 303 WP_064483783.1 XRE family transcriptional regulator Antitoxin
LLY23_RS12650 (LLY23_12670) 2532245..2532598 - 354 WP_064483784.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLY23_RS12655 (LLY23_12675) 2532875..2533927 + 1053 WP_015422620.1 dihydroorotase -
LLY23_RS12660 (LLY23_12680) 2534162..2534419 + 258 WP_004236879.1 biofilm formation regulator BssS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13576.57 Da        Isoelectric Point: 10.1577

>T222743 WP_064483784.1 NZ_CP086203:c2532598-2532245 [Morganella morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFAPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T222743 NZ_CP118097:c294881-294627 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11088.95 Da        Isoelectric Point: 8.5562

>AT222743 WP_064483783.1 NZ_CP086203:c2532242-2531940 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGHDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT222743 NZ_CP118097:c295140-294874 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References