Detailed information of TA system TA222743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2531940..2532598
• Replicon: chromosome
• Accession: NZ_CP086203
• Organism: Morganella morganii strain MMAS2018

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LLY23_RS12650
• Protein ID: WP_064483784.1
• Coordinates: 2532245..2532598 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LLY23_RS12645
• Protein ID: WP_064483783.1
• Coordinates: 2531940..2532242 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLY23_RS12605 (LLY23_12625)	2528305..2529000	-	696	WP_004240015.1	MgtC family protein	-
LLY23_RS12610 (LLY23_12630)	2529351..2529545	-	195	WP_015422621.1	protein DsrB	-
LLY23_RS12615 (LLY23_12635)	2529649..2529861	-	213	WP_004240014.1	transcription antiterminator/RNA stability regulator CspE	-
LLY23_RS12620 (LLY23_12640)	2530322..2530831	+	510	WP_004240013.1	YlaC family protein	-
LLY23_RS12645 (LLY23_12665)	2531940..2532242	-	303	WP_064483783.1	XRE family transcriptional regulator	Antitoxin
LLY23_RS12650 (LLY23_12670)	2532245..2532598	-	354	WP_064483784.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LLY23_RS12655 (LLY23_12675)	2532875..2533927	+	1053	WP_015422620.1	dihydroorotase	-
LLY23_RS12660 (LLY23_12680)	2534162..2534419	+	258	WP_004236879.1	biofilm formation regulator BssS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13576.57 Da
• Isoelectric Point: 10.1577

>T222743 WP_064483784.1 NZ_CP086203:c2532598-2532245 [Morganella morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFAPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Nucleotide

• Length: 354 bp

>T222743 NZ_CP118097:c294881-294627 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11088.95 Da
• Isoelectric Point: 8.5562

>AT222743 WP_064483783.1 NZ_CP086203:c2532242-2531940 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGHDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Nucleotide

• Length: 303 bp

>AT222743 NZ_CP118097:c295140-294874 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA