Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2269599..2269862 Replicon chromosome
Accession NC_009641
Organism Staphylococcus aureus subsp. aureus str. Newman

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag NWMN_RS11845 Protein ID WP_001802298.1
Coordinates 2269758..2269862 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2269599..2269763 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWMN_RS11825 (NWMN_2048) 2265848..2266513 - 666 WP_001024094.1 SDR family oxidoreductase -
NWMN_RS11830 (NWMN_2049) 2266665..2266985 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
NWMN_RS11835 (NWMN_2050) 2266987..2267967 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
NWMN_RS11840 (NWMN_2051) 2268233..2269324 + 1092 WP_000495671.1 lytic regulatory protein -
- 2269599..2269763 + 165 - - Antitoxin
NWMN_RS11845 2269758..2269862 - 105 WP_001802298.1 hypothetical protein Toxin
NWMN_RS15780 2270023..2270506 - 484 Protein_2247 recombinase family protein -
NWMN_RS11855 (NWMN_2053) 2270549..2271685 - 1137 WP_000115564.1 SAP domain-containing protein -
NWMN_RS11860 2271974..2272066 + 93 WP_001790138.1 hypothetical protein -
NWMN_RS11865 (NWMN_2054) 2272771..2273628 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
NWMN_RS11870 (NWMN_2055) 2273696..2274478 - 783 WP_000908177.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T22273 WP_001802298.1 NC_009641:c2269862-2269758 [Staphylococcus aureus subsp. aureus str. Newman]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T22273 NC_009641:c2269862-2269758 [Staphylococcus aureus subsp. aureus str. Newman]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT22273 NC_009641:2269599-2269763 [Staphylococcus aureus subsp. aureus str. Newman]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References