Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3411283..3411926 Replicon chromosome
Accession NZ_CP086177
Organism Streptomyces fungicidicus strain F7

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag LL040_RS15220 Protein ID WP_121546428.1
Coordinates 3411283..3411624 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag LL040_RS15225 Protein ID WP_121546429.1
Coordinates 3411621..3411926 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL040_RS15205 3407211..3408809 - 1599 WP_121546425.1 carboxyl transferase domain-containing protein -
LL040_RS15210 3408806..3410482 - 1677 WP_121546426.1 acyclic terpene utilization AtuA family protein -
LL040_RS15215 3410479..3411273 - 795 WP_121546427.1 TIGR03084 family metal-binding protein -
LL040_RS15220 3411283..3411624 + 342 WP_121546428.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL040_RS15225 3411621..3411926 + 306 WP_121546429.1 helix-turn-helix transcriptional regulator Antitoxin
LL040_RS15230 3412001..3412981 - 981 WP_121546430.1 EamA family transporter -
LL040_RS15235 3413240..3413692 + 453 WP_121546431.1 NUDIX domain-containing protein -
LL040_RS15240 3413724..3416585 - 2862 WP_121546432.1 FAD-binding and (Fe-S)-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13063.15 Da        Isoelectric Point: 11.4533

>T222643 WP_121546428.1 NZ_CP086177:3411283-3411624 [Streptomyces fungicidicus]
MAAPPKTIKHACWLLPRPQREVGPALRRPTVGAIERSRFRNMRELRPRNGGTVSIRMLFVFDPERRAIFLVAGNKATGRR
WASWYPRAIKEADDKYTAYLEALEQEKKEGQGR

Download         Length: 342 bp

>T222643 NZ_CP117979:c2275481-2275329 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10854.41 Da        Isoelectric Point: 6.4671

>AT222643 WP_121546429.1 NZ_CP086177:3411621-3411926 [Streptomyces fungicidicus]
MNLGSMDDLTADITPEKRERIDAIKAEMIDAERGHELAALRKAQGFTQVQVAKAMGVTQGRVSQIERGTARLDTSTMAAY
LHAIGGELTITATVGNLSVRL

Download         Length: 306 bp

>AT222643 NZ_CP117979:c2276105-2275506 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAATATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References