Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3410848..3411491 Replicon chromosome
Accession NZ_CP086174
Organism Streptomyces fungicidicus strain F10

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag LL043_RS15220 Protein ID WP_121546428.1
Coordinates 3410848..3411189 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag LL043_RS15225 Protein ID WP_121546429.1
Coordinates 3411186..3411491 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL043_RS15205 3406776..3408374 - 1599 WP_121546425.1 carboxyl transferase domain-containing protein -
LL043_RS15210 3408371..3410047 - 1677 WP_121546426.1 acyclic terpene utilization AtuA family protein -
LL043_RS15215 3410044..3410838 - 795 WP_121546427.1 TIGR03084 family metal-binding protein -
LL043_RS15220 3410848..3411189 + 342 WP_121546428.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL043_RS15225 3411186..3411491 + 306 WP_121546429.1 helix-turn-helix transcriptional regulator Antitoxin
LL043_RS15230 3411566..3412546 - 981 WP_121546430.1 EamA family transporter -
LL043_RS15235 3412805..3413257 + 453 WP_121546431.1 NUDIX domain-containing protein -
LL043_RS15240 3413289..3416150 - 2862 WP_121546432.1 FAD-binding and (Fe-S)-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13063.15 Da        Isoelectric Point: 11.4533

>T222631 WP_121546428.1 NZ_CP086174:3410848-3411189 [Streptomyces fungicidicus]
MAAPPKTIKHACWLLPRPQREVGPALRRPTVGAIERSRFRNMRELRPRNGGTVSIRMLFVFDPERRAIFLVAGNKATGRR
WASWYPRAIKEADDKYTAYLEALEQEKKEGQGR

Download         Length: 342 bp

>T222631 NZ_CP117976:c1530538-1530281 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGTATAACCACCTGTTACTCACAAATCCCCAGCCT
GCACCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10854.41 Da        Isoelectric Point: 6.4671

>AT222631 WP_121546429.1 NZ_CP086174:3411186-3411491 [Streptomyces fungicidicus]
MNLGSMDDLTADITPEKRERIDAIKAEMIDAERGHELAALRKAQGFTQVQVAKAMGVTQGRVSQIERGTARLDTSTMAAY
LHAIGGELTITATVGNLSVRL

Download         Length: 306 bp

>AT222631 NZ_CP117976:1530363-1530685 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCCGGGGCCGTAT
TTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References