Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3410848..3411491 Replicon chromosome
Accession NZ_CP086173
Organism Streptomyces fungicidicus strain ATCC 21013

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag LL044_RS15220 Protein ID WP_121546428.1
Coordinates 3410848..3411189 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag LL044_RS15225 Protein ID WP_121546429.1
Coordinates 3411186..3411491 (+) Length 102 a.a.

Genomic Context

LL044_RS15220LL044_RS15225LL044_RS15235LL044_RS15205LL044_RS15210LL044_RS15215LL044_RS15230LL044_RS15240
Location: 3410848..3411189 (342 bp)
Type: Toxin
Protein ID: WP_121546428.1
Location: 3411186..3411491 (306 bp)
Type: Antitoxin
Protein ID: WP_121546429.1
Location: 3412805..3413257 (453 bp)
Type: Others
Protein ID: WP_121546431.1
Location: 3406776..3408374 (1599 bp)
Type: Others
Protein ID: WP_121546425.1
Location: 3408371..3410047 (1677 bp)
Type: Others
Protein ID: WP_121546426.1
Location: 3410044..3410838 (795 bp)
Type: Others
Protein ID: WP_121546427.1
Location: 3411566..3412546 (981 bp)
Type: Others
Protein ID: WP_121546430.1
Location: 3413289..3416150 (2862 bp)
Type: Others
Protein ID: WP_121546432.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LL044_RS152053406776..3408374-1599WP_121546425.1carboxyl transferase domain-containing protein-
LL044_RS152103408371..3410047-1677WP_121546426.1acyclic terpene utilization AtuA family protein-
LL044_RS152153410044..3410838-795WP_121546427.1TIGR03084 family metal-binding protein-
LL044_RS152203410848..3411189+342WP_121546428.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LL044_RS152253411186..3411491+306WP_121546429.1helix-turn-helix transcriptional regulatorAntitoxin
LL044_RS152303411566..3412546-981WP_121546430.1EamA family transporter-
LL044_RS152353412805..3413257+453WP_121546431.1NUDIX domain-containing protein-
LL044_RS152403413289..3416150-2862WP_121546432.1FAD-binding and (Fe-S)-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13063.15 Da        Isoelectric Point: 11.4533

>T222627 WP_121546428.1 NZ_CP086173:3410848-3411189 [Streptomyces fungicidicus]
MAAPPKTIKHACWLLPRPQREVGPALRRPTVGAIERSRFRNMRELRPRNGGTVSIRMLFVFDPERRAIFLVAGNKATGRR
WASWYPRAIKEADDKYTAYLEALEQEKKEGQGR

Download         Length: 342 bp

>T222627 NZ_CP117976:c87740-87222 [Salmonella enterica]
GTGGACAACCTGACAATAGAGATTCTGGCTGATAACGCAGAATACAACTGGCGGCAGTTCGACTGCGGTGAGGCATCATT
AAACCTTTTTTTAACGCAGCATCTTCAGCGCCAGCATAACAACAAAATCTTGCGCGGTTATGTACTCAGAACCACTACGC
CAGAACGGCGAGTGTTGGGGTATTACACCCTGTCAGGAAGCTGCTTTGAACGCGCGTCGTTGCCTTCCAGAACCCAGCAA
AAGCGCATCCCTTACCAGAATATCCCCAGCGTTACGCTGGGCCGTTTAGCGGTCGATCTCTCATTACAGGGAAAAGGGTG
GGGAGCCATATTGGTCACGCATGCGATGAAAGTGGTGTGGTCGGCATCACTGGCCGTTGGGATTCATGGCATCTTTGTGG
AAGCGTTAAACGAAAAAGCCCAGGCCTTTTATCAGAGGCTGGGCTTTATTTCTTTATCCGGAGAAAACGAGCACGCGCTG
TTTTACCCGACAAAATCGATTGAGCAACTTTTTGGCTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10854.41 Da        Isoelectric Point: 6.4671

>AT222627 WP_121546429.1 NZ_CP086173:3411186-3411491 [Streptomyces fungicidicus]
MNLGSMDDLTADITPEKRERIDAIKAEMIDAERGHELAALRKAQGFTQVQVAKAMGVTQGRVSQIERGTARLDTSTMAAY
LHAIGGELTITATVGNLSVRL

Download         Length: 306 bp

>AT222627 NZ_CP117976:c88013-87744 [Salmonella enterica]
ATGTCAGCCCTAAAAAAACAGCGTATCGATCTGCGGCTCACAGACGGCGATAAAAGCATGATTGAAGAAGCGGCCGCCAT
TACTAATCAATCAATCACGCAATTTATGTTGAATAGCGCAGCGGAGCGAGCCGCAGAAGTGCTTGAACAGCACCGTCGGG
TTATTCTTAATGAAGCATCCTGGGCGCGAGTCATGGATGCGCTTAGTCATCCTCCCACCCCCAATGAGAAATTAAAACGC
GCGGCGCAACGTCTACAAGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References