Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3160787..3161385 | Replicon | chromosome |
| Accession | NZ_CP086136 | ||
| Organism | Bradyrhizobium barranii subsp. barranii strain 144S4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | J4G43_RS15250 | Protein ID | WP_208085265.1 |
| Coordinates | 3160787..3161071 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J4G43_RS15255 | Protein ID | WP_208089326.1 |
| Coordinates | 3161083..3161385 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4G43_RS15230 (J4G43_015275) | 3155889..3156809 | - | 921 | WP_208085263.1 | SWIM zinc finger family protein | - |
| J4G43_RS15235 (J4G43_015280) | 3156810..3158810 | - | 2001 | WP_225004917.1 | DEAD/DEAH box helicase | - |
| J4G43_RS15240 (J4G43_015285) | 3158818..3159580 | - | 763 | Protein_3030 | IS6 family transposase | - |
| J4G43_RS15245 (J4G43_015290) | 3159751..3160035 | - | 285 | WP_225004919.1 | DUF3892 domain-containing protein | - |
| J4G43_RS15250 (J4G43_015295) | 3160787..3161071 | + | 285 | WP_208085265.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J4G43_RS15255 (J4G43_015300) | 3161083..3161385 | + | 303 | WP_208089326.1 | HigA family addiction module antitoxin | Antitoxin |
| J4G43_RS15260 (J4G43_015305) | 3161720..3162028 | - | 309 | WP_208085266.1 | HigA family addiction module antitoxin | - |
| J4G43_RS15265 (J4G43_015310) | 3162091..3162339 | - | 249 | WP_225005704.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J4G43_RS15270 (J4G43_015315) | 3162709..3163523 | - | 815 | Protein_3036 | IS110 family transposase | - |
| J4G43_RS15275 (J4G43_015320) | 3164114..3164374 | + | 261 | WP_225005706.1 | XRE family transcriptional regulator | - |
| J4G43_RS15280 (J4G43_015325) | 3164349..3165221 | - | 873 | WP_208085268.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3115546..3166079 | 50533 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10910.53 Da Isoelectric Point: 10.3116
>T222618 WP_208085265.1 NZ_CP086136:3160787-3161071 [Bradyrhizobium barranii subsp. barranii]
MAIRSFRDTDARAVFDGSCPRGFPASIVRVARRKLRMIDAAKELVDLKAPPNNKLHELDRDRKGQHAIWINRQYRVCFVW
KDGDASKVEITDYH
MAIRSFRDTDARAVFDGSCPRGFPASIVRVARRKLRMIDAAKELVDLKAPPNNKLHELDRDRKGQHAIWINRQYRVCFVW
KDGDASKVEITDYH
Download Length: 285 bp
>T222618 NZ_CP117974:c1631645-1631067 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
Antitoxin
Download Length: 101 a.a. Molecular weight: 11499.32 Da Isoelectric Point: 7.2783
>AT222618 WP_208089326.1 NZ_CP086136:3161083-3161385 [Bradyrhizobium barranii subsp. barranii]
IMAKLKPLHPGEVLREEFMGPYHLTPYALANLCHIPRTRIERIVREESGITADTALRLARVFGTTPDFWLTLQSRYEVEK
TEAEISRELKDIKPREPVAA
IMAKLKPLHPGEVLREEFMGPYHLTPYALANLCHIPRTRIERIVREESGITADTALRLARVFGTTPDFWLTLQSRYEVEK
TEAEISRELKDIKPREPVAA
Download Length: 303 bp
>AT222618 NZ_CP117974:c1632288-1631734 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|