222611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3791691..3792343 Replicon chromosome
Accession NZ_CP086133
Organism Pantoea agglomerans strain DBM 3797

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8DRT2
Locus tag LKW31_RS17755 Protein ID WP_010672045.1
Coordinates 3791691..3792044 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8X8DRN0
Locus tag LKW31_RS17760 Protein ID WP_010252120.1
Coordinates 3792044..3792343 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW31_RS17740 (3787417) 3787417..3789201 - 1785 WP_172608722.1 GMC family oxidoreductase -
LKW31_RS17745 (3789204) 3789204..3789938 - 735 WP_010672043.1 gluconate 2-dehydrogenase subunit 3 family protein -
LKW31_RS17750 (3790215) 3790215..3791456 + 1242 WP_033770848.1 peptide antibiotic transporter SbmA -
LKW31_RS17755 (3791691) 3791691..3792044 + 354 WP_010672045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LKW31_RS17760 (3792044) 3792044..3792343 + 300 WP_010252120.1 XRE family transcriptional regulator Antitoxin
LKW31_RS17765 (3792466) 3792466..3793518 - 1053 WP_060681537.1 YncE family protein -
LKW31_RS17770 (3793721) 3793721..3793930 - 210 WP_009092571.1 DUF1471 domain-containing protein -
LKW31_RS17775 (3794143) 3794143..3795330 - 1188 WP_010252123.1 MFS transporter -
LKW31_RS17780 (3795435) 3795435..3796400 + 966 WP_010252125.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13660.67 Da        Isoelectric Point: 7.9792

>T222611 WP_010672045.1 NZ_CP086133:3791691-3792044 [Pantoea agglomerans]
MWTVLLSPRFESWLSEQEEALQEKMLADLGKLKVYGPDLPRPYADTLKGSQYRNMKELRVQFSGKPIRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Download         Length: 354 bp

>T222611 NZ_CP117971:3923111-3923329 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11116.99 Da        Isoelectric Point: 6.3781

>AT222611 WP_010252120.1 NZ_CP086133:3792044-3792343 [Pantoea agglomerans]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYVEAMG
GKLSLDVELPTGKRVAFRI

Download         Length: 300 bp

>AT222611 NZ_CP117971:3922711-3923085 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References