Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1883912..1884425 Replicon chromosome
Accession NZ_CP086130
Organism Streptococcus agalactiae strain MIN-180

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag LLZ83_RS09625 Protein ID WP_000481712.1
Coordinates 1883912..1884166 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag LLZ83_RS09630 Protein ID WP_000387490.1
Coordinates 1884159..1884425 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ83_RS09605 (LLZ83_09600) 1879683..1882184 - 2502 WP_000239404.1 ATP-binding protein -
LLZ83_RS09610 (LLZ83_09605) 1882205..1882615 - 411 WP_000390749.1 conjugal transfer protein -
LLZ83_RS09615 (LLZ83_09610) 1882619..1882885 - 267 WP_001055037.1 hypothetical protein -
LLZ83_RS09620 (LLZ83_09615) 1882906..1883859 - 954 WP_000565541.1 conjugal transfer protein -
LLZ83_RS09625 (LLZ83_09620) 1883912..1884166 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
LLZ83_RS09630 (LLZ83_09625) 1884159..1884425 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LLZ83_RS09635 (LLZ83_09630) 1884570..1885043 - 474 WP_000560386.1 hypothetical protein -
LLZ83_RS09640 (LLZ83_09635) 1885051..1885533 - 483 WP_000383283.1 antirestriction protein ArdA -
LLZ83_RS09645 (LLZ83_09640) 1885586..1885858 - 273 WP_000072643.1 hypothetical protein -
LLZ83_RS09650 (LLZ83_09645) 1885990..1886343 - 354 WP_000571928.1 helix-turn-helix transcriptional regulator -
LLZ83_RS09655 (LLZ83_09650) 1886336..1886566 - 231 WP_001866982.1 helix-turn-helix transcriptional regulator -
LLZ83_RS09660 (LLZ83_09655) 1886553..1886930 - 378 WP_000287185.1 hypothetical protein -
LLZ83_RS09665 (LLZ83_09660) 1886946..1888178 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1868745..1908347 39602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T222598 WP_000481712.1 NZ_CP086130:c1884166-1883912 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T222598 NZ_CP117971:997119-997433 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT222598 WP_000387490.1 NZ_CP086130:c1884425-1884159 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT222598 NZ_CP117971:997430-997846 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References