Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 353223..353869 | Replicon | chromosome |
Accession | NZ_CP086128 | ||
Organism | Klebsiella pneumoniae strain MIN-109 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A483JFR4 |
Locus tag | LLZ91_RS01620 | Protein ID | WP_004188313.1 |
Coordinates | 353223..353570 (+) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A483GM64 |
Locus tag | LLZ91_RS01625 | Protein ID | WP_004188315.1 |
Coordinates | 353570..353869 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LLZ91_RS01610 (LLZ91_01610) | 349149..350582 | + | 1434 | WP_002920564.1 | glycogen synthase GlgA | - |
LLZ91_RS01615 (LLZ91_01615) | 350600..353047 | + | 2448 | WP_002920561.1 | glycogen phosphorylase | - |
LLZ91_RS01620 (LLZ91_01620) | 353223..353570 | + | 348 | WP_004188313.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LLZ91_RS01625 (LLZ91_01625) | 353570..353869 | + | 300 | WP_004188315.1 | XRE family transcriptional regulator | Antitoxin |
LLZ91_RS01630 (LLZ91_01630) | 353932..355440 | - | 1509 | WP_002920554.1 | glycerol-3-phosphate dehydrogenase | - |
LLZ91_RS01635 (LLZ91_01635) | 355645..355974 | + | 330 | WP_002920552.1 | thiosulfate sulfurtransferase GlpE | - |
LLZ91_RS01640 (LLZ91_01640) | 356025..356855 | + | 831 | WP_004188317.1 | rhomboid family intramembrane serine protease GlpG | - |
LLZ91_RS01645 (LLZ91_01645) | 356905..357663 | + | 759 | WP_002920548.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13548.57 Da Isoelectric Point: 6.2327
>T222582 WP_004188313.1 NZ_CP086128:353223-353570 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER
Download Length: 348 bp
>T222582 NZ_CP117967:44015-44281 [Veillonella rogosae]
ATGGCTTATAAACTTGAATTTTCTAAACGGTTTGACAAGCAATTTTCTAAATTAGATAAATCAACGCAACGCTATCTTTT
TAATTGGCTTATAAAGAATGTAGATAATGTAGAAAATCCTAGATACTCAGGAAAATCATTGACGGGGAATAAAACAGGGC
TGTGGCGTTATCGCATTGGTAATCATAGAGTTATTGCTGATATTAATGGCTATAGATGCATCATTTTAGCGCTAGAAGTT
GGTCATCGAAAAGACATTTACAAATAG
ATGGCTTATAAACTTGAATTTTCTAAACGGTTTGACAAGCAATTTTCTAAATTAGATAAATCAACGCAACGCTATCTTTT
TAATTGGCTTATAAAGAATGTAGATAATGTAGAAAATCCTAGATACTCAGGAAAATCATTGACGGGGAATAAAACAGGGC
TGTGGCGTTATCGCATTGGTAATCATAGAGTTATTGCTGATATTAATGGCTATAGATGCATCATTTTAGCGCTAGAAGTT
GGTCATCGAAAAGACATTTACAAATAG
Antitoxin
Download Length: 100 a.a. Molecular weight: 10873.64 Da Isoelectric Point: 10.1464
>AT222582 WP_004188315.1 NZ_CP086128:353570-353869 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL
Download Length: 300 bp
>AT222582 NZ_CP117967:43804-44025 [Veillonella rogosae]
ATGGCGAATATTTCAGTCCGTCTAAATGAACAAGAAGAAGAGTTATTTAAAACCTATGCTGAGTTTATGGATGAAACACT
TTCTACCCTCTTTAAGAAGGCTTTGCTAGAAAAGATTGAAGACGAATTTGATCTTAAGGTAGGTCAAAAAGCATTAGCAG
AATACGAGCAAGATCCAGTTACCTATTCTGTGGCGGAAATGCGTGCAAAATATGGCTTATAA
ATGGCGAATATTTCAGTCCGTCTAAATGAACAAGAAGAAGAGTTATTTAAAACCTATGCTGAGTTTATGGATGAAACACT
TTCTACCCTCTTTAAGAAGGCTTTGCTAGAAAAGATTGAAGACGAATTTGATCTTAAGGTAGGTCAAAAAGCATTAGCAG
AATACGAGCAAGATCCAGTTACCTATTCTGTGGCGGAAATGCGTGCAAAATATGGCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A483JFR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A483GM64 |