Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5179099..5179634 Replicon chromosome
Accession NZ_CP086119
Organism Streptomyces huasconensis strain D23

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag J2N69_RS23795 Protein ID WP_230902546.1
Coordinates 5179380..5179634 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag J2N69_RS23790 Protein ID WP_230902545.1
Coordinates 5179099..5179383 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J2N69_RS23770 (J2N69_23785) 5175201..5176193 + 993 WP_230902541.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
J2N69_RS23775 (J2N69_23790) 5176216..5176959 + 744 WP_230902542.1 ROK family protein -
J2N69_RS23780 (J2N69_23795) 5177004..5177633 - 630 WP_230902543.1 hypothetical protein -
J2N69_RS23785 (J2N69_23800) 5177858..5178946 + 1089 WP_230902544.1 redox-regulated ATPase YchF -
J2N69_RS23790 (J2N69_23805) 5179099..5179383 + 285 WP_230902545.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J2N69_RS23795 (J2N69_23810) 5179380..5179634 + 255 WP_230902546.1 Txe/YoeB family addiction module toxin Toxin
J2N69_RS23800 (J2N69_23815) 5179804..5180982 - 1179 WP_230902547.1 serine/threonine-protein kinase -
J2N69_RS23805 (J2N69_23820) 5180982..5182754 - 1773 WP_230902548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10099.60 Da        Isoelectric Point: 7.3149

>T222570 WP_230902546.1 NZ_CP086119:5179380-5179634 [Streptomyces huasconensis]
VRLVFEDQGWEDYTSWLKDDRKMLARINKLIEDVKRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T222570 NZ_CP117962:3117393-3117800 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10095.25 Da        Isoelectric Point: 4.6652

>AT222570 WP_230902545.1 NZ_CP086119:5179099-5179383 [Streptomyces huasconensis]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLRAYENALGDSNVSEREL
IDPDSADVAGEGAA

Download         Length: 285 bp

>AT222570 NZ_CP117962:3117146-3117412 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References