222560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2453895..2454417 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LLY43_RS11980 Protein ID WP_000221343.1
Coordinates 2454133..2454417 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LLY43_RS11975 Protein ID WP_000885424.1
Coordinates 2453895..2454143 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS11950 (2449111) 2449111..2450577 + 1467 WP_000987828.1 hypothetical protein -
LLY43_RS11955 (2451385) 2451385..2452099 + 715 Protein_2341 helix-turn-helix domain-containing protein -
LLY43_RS11960 (2452155) 2452155..2453063 - 909 WP_010989018.1 hypothetical protein -
LLY43_RS11965 (2453206) 2453206..2453538 - 333 WP_000253154.1 DUF1493 family protein -
LLY43_RS11970 (2453528) 2453528..2453743 - 216 WP_000206207.1 hypothetical protein -
LLY43_RS11975 (2453895) 2453895..2454143 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LLY43_RS11980 (2454133) 2454133..2454417 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLY43_RS11985 (2454588) 2454588..2454977 + 390 WP_000194089.1 RidA family protein -
LLY43_RS11990 (2455029) 2455029..2456108 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LLY43_RS11995 (2456301) 2456301..2456789 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
LLY43_RS12000 (2456834) 2456834..2458342 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2449114..2461199 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T222560 WP_000221343.1 NZ_CP086118:2454133-2454417 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T222560 NZ_CP117962:389961-390068 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT222560 WP_000885424.1 NZ_CP086118:2453895-2454143 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT222560 NZ_CP117962:c389911-389848 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References