Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 364798..365336 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LLY43_RS01655 Protein ID WP_001526148.1
Coordinates 365061..365336 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LLY43_RS01650 Protein ID WP_000729713.1
Coordinates 364798..365058 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS01630 (360351) 360351..361904 + 1554 WP_000013007.1 TROVE domain-containing protein -
LLY43_RS01635 (361913) 361913..362104 + 192 Protein_324 TROVE domain-containing protein -
LLY43_RS01640 (362452) 362452..363666 + 1215 WP_001105521.1 RNA-splicing ligase RtcB -
LLY43_RS01645 (363670) 363670..364689 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
LLY43_RS01650 (364798) 364798..365058 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LLY43_RS01655 (365061) 365061..365336 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LLY43_RS01660 (365424) 365424..368129 - 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T222548 WP_001526148.1 NZ_CP086118:365061-365336 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T222548 NZ_CP117960:3673897-3674232 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT222548 WP_000729713.1 NZ_CP086118:364798-365058 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT222548 NZ_CP117960:3673649-3673897 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCAGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References