Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2601235..2601823 Replicon chromosome
Accession NZ_CP086111
Organism Skermanella rosea strain KEMB 2255-458

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JL101_RS11940 Protein ID WP_203095261.1
Coordinates 2601235..2601513 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JL101_RS11945 Protein ID WP_202679541.1
Coordinates 2601536..2601823 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL101_RS11915 (JL101_011950) 2596726..2597301 - 576 WP_203095257.1 protein-tyrosine-phosphatase -
JL101_RS11920 (JL101_011955) 2597440..2598543 + 1104 WP_203095258.1 alpha/beta fold hydrolase -
JL101_RS11925 (JL101_011960) 2598608..2598784 + 177 WP_201081744.1 hypothetical protein -
JL101_RS11930 (JL101_011965) 2598899..2600290 + 1392 WP_203095259.1 dipeptidase -
JL101_RS11935 (JL101_011970) 2600296..2601084 - 789 WP_203095260.1 3'-5' exonuclease -
JL101_RS11940 (JL101_011975) 2601235..2601513 + 279 WP_203095261.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL101_RS11945 (JL101_011980) 2601536..2601823 + 288 WP_202679541.1 HigA family addiction module antitoxin Antitoxin
JL101_RS11950 (JL101_011985) 2602028..2602435 + 408 WP_228435487.1 GAF domain-containing protein -
JL101_RS11955 (JL101_011990) 2602501..2604033 + 1533 WP_203095263.1 altronate dehydratase family protein -
JL101_RS11960 (JL101_011995) 2604071..2604922 + 852 WP_203095264.1 fumarylacetoacetate hydrolase family protein -
JL101_RS11965 (JL101_012000) 2604935..2605537 - 603 WP_203095265.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10471.87 Da        Isoelectric Point: 7.7540

>T222535 WP_203095261.1 NZ_CP086111:2601235-2601513 [Skermanella rosea]
MIKSFRDKTTEELFRLGSARRFSSVSKVASRKLDMINAAIALDDLRSPPGNRLEALKGDRCGQHSICINEQWRICFRWSG
DGADDVEIVDYH

Download         Length: 279 bp

>T222535 NZ_CP117960:c367068-366892 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10630.16 Da        Isoelectric Point: 8.6592

>AT222535 WP_202679541.1 NZ_CP086111:2601536-2601823 [Skermanella rosea]
MRLKTHPGEVLREEFLAPLGLSANALATALRVPVTRISEIIHERRAVTADTALRLGRYFGTSPEFWMNLQQAYDLSVVAR
DRGGDIERDVQPRAA

Download         Length: 288 bp

>AT222535 NZ_CP117960:c366846-366430 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References