Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2750166..2750754 Replicon chromosome
Accession NZ_CP086106
Organism Skermanella mucosa strain KEMB 2255-438

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JL100_RS12515 Protein ID WP_202679540.1
Coordinates 2750476..2750754 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JL100_RS12510 Protein ID WP_202679541.1
Coordinates 2750166..2750453 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL100_RS12490 (JL100_012530) 2746440..2747027 + 588 WP_202679545.1 hypothetical protein -
JL100_RS12495 (JL100_012535) 2747040..2747891 - 852 WP_202679544.1 ureidoglycolate lyase -
JL100_RS12500 (JL100_012540) 2747929..2749461 - 1533 WP_202679543.1 altronate dehydratase family protein -
JL100_RS12505 (JL100_012545) 2749527..2749934 - 408 WP_228421348.1 GAF domain-containing protein -
JL100_RS12510 (JL100_012550) 2750166..2750453 - 288 WP_202679541.1 HigA family addiction module antitoxin Antitoxin
JL100_RS12515 (JL100_012555) 2750476..2750754 - 279 WP_202679540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL100_RS12520 (JL100_012560) 2750929..2751717 + 789 WP_202679539.1 3'-5' exonuclease -
JL100_RS12525 (JL100_012565) 2751724..2753115 - 1392 WP_202679538.1 dipeptidase -
JL100_RS12530 (JL100_012570) 2753230..2753406 - 177 WP_202679907.1 hypothetical protein -
JL100_RS12535 (JL100_012575) 2753471..2754562 - 1092 WP_202679537.1 alpha/beta fold hydrolase -
JL100_RS12540 (JL100_012580) 2754701..2755276 + 576 WP_202679536.1 protein-tyrosine-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10599.03 Da        Isoelectric Point: 9.1457

>T222526 WP_202679540.1 NZ_CP086106:c2750754-2750476 [Skermanella mucosa]
MIKSFRDKTTEELFRLGSARRFSSISKVALRKLDMINAAIALDDLRSPPGNRLEALKGDRHGQHSIRINEQWRICFRWSG
DGADDVEIVDYH

Download         Length: 279 bp

>T222526 NZ_CP117959:3247553-3248017 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10630.16 Da        Isoelectric Point: 8.6592

>AT222526 WP_202679541.1 NZ_CP086106:c2750453-2750166 [Skermanella mucosa]
MRLKTHPGEVLREEFLAPLGLSANALATALRVPVTRISEIIHERRAVTADTALRLGRYFGTSPEFWMNLQQAYDLSVVAR
DRGGDIERDVQPRAA

Download         Length: 288 bp

>AT222526 NZ_CP117959:3247218-3247553 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References