Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/MqsA(antitoxin) |
| Location | 459068..459720 | Replicon | plasmid megaplasmid |
| Accession | NZ_CP086105 | ||
| Organism | Ralstonia sp. RS650 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LGV82_RS19985 | Protein ID | WP_247393979.1 |
| Coordinates | 459376..459720 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LGV82_RS19980 | Protein ID | WP_020425351.1 |
| Coordinates | 459068..459379 (-) | Length | 104 a.a. |
Genomic Context
Location: 458119..458928 (810 bp)
Type: Others
Protein ID: WP_043885575.1
Type: Others
Protein ID: WP_043885575.1
Location: 461914..462810 (897 bp)
Type: Others
Protein ID: WP_071092368.1
Type: Others
Protein ID: WP_071092368.1
Location: 462862..464025 (1164 bp)
Type: Others
Protein ID: WP_118872529.1
Type: Others
Protein ID: WP_118872529.1
Location: 455036..456832 (1797 bp)
Type: Others
Protein ID: WP_058907709.1
Type: Others
Protein ID: WP_058907709.1
Location: 459068..459379 (312 bp)
Type: Antitoxin
Protein ID: WP_020425351.1
Type: Antitoxin
Protein ID: WP_020425351.1
Location: 459376..459720 (345 bp)
Type: Toxin
Protein ID: WP_247393979.1
Type: Toxin
Protein ID: WP_247393979.1
Location: 459771..461720 (1950 bp)
Type: Others
Protein ID: WP_247393981.1
Type: Others
Protein ID: WP_247393981.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGV82_RS19970 (LGV82_19965) | 455036..456832 | - | 1797 | WP_058907709.1 | 3'-5' exonuclease | - |
| LGV82_RS19975 (LGV82_19970) | 458119..458928 | + | 810 | WP_043885575.1 | DUF2242 domain-containing protein | - |
| LGV82_RS19980 (LGV82_19975) | 459068..459379 | - | 312 | WP_020425351.1 | transcriptional regulator | Antitoxin |
| LGV82_RS19985 (LGV82_19980) | 459376..459720 | - | 345 | WP_247393979.1 | toxin | Toxin |
| LGV82_RS19990 (LGV82_19985) | 459771..461720 | - | 1950 | WP_247393981.1 | propionate catabolism operon regulatory protein PrpR | - |
| LGV82_RS19995 (LGV82_19990) | 461914..462810 | + | 897 | WP_071092368.1 | methylisocitrate lyase | - |
| LGV82_RS20000 (LGV82_19995) | 462862..464025 | + | 1164 | WP_118872529.1 | 2-methylcitrate synthase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | fliI / fliG / fliM / flgG / flgC / cyaB / motA / cheW / cheB / cheY / adeG / acrB | 1..2073962 | 2073962 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13276.03 Da Isoelectric Point: 9.3395
>T222521 WP_247393979.1 NZ_CP086105:c459720-459376 [Ralstonia sp. RS650]
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGYVIKGTGGLRKLRFSDKRRGKGKRGGLRVIDYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGYVIKGTGGLRKLRFSDKRRGKGKRGGLRVIDYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER
Download Length: 345 bp
>T222521 NZ_CP117959:c2792214-2791879 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 104 a.a. Molecular weight: 11619.65 Da Isoelectric Point: 10.7132
>AT222521 WP_020425351.1 NZ_CP086105:c459379-459068 [Ralstonia sp. RS650]
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL
Download Length: 312 bp
>AT222521 NZ_CP117959:c2792462-2792214 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA