Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5222139..5222647 Replicon chromosome
Accession NZ_CP086102
Organism Streptomyces anulatus strain YINM00001

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LK895_RS22460 Protein ID WP_164216356.1
Coordinates 5222139..5222399 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C4HSG8
Locus tag LK895_RS22465 Protein ID WP_050358889.1
Coordinates 5222396..5222647 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK895_RS22435 5217428..5217799 + 372 WP_047177075.1 hypothetical protein -
LK895_RS22440 5217958..5218824 + 867 WP_087766158.1 TatD family hydrolase -
LK895_RS22445 5218896..5219771 + 876 WP_087766159.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LK895_RS22450 5219777..5220676 + 900 WP_164340640.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
LK895_RS22455 5220766..5222151 + 1386 WP_228182568.1 acyltransferase -
LK895_RS22460 5222139..5222399 - 261 WP_164216356.1 Txe/YoeB family addiction module toxin Toxin
LK895_RS22465 5222396..5222647 - 252 WP_050358889.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LK895_RS22470 5222751..5223830 - 1080 WP_228182569.1 hypothetical protein -
LK895_RS22475 5223937..5224674 - 738 WP_228182570.1 lipoprotein -
LK895_RS22480 5224822..5226639 + 1818 WP_087766164.1 ABC-F family ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10422.76 Da        Isoelectric Point: 9.4245

>T222516 WP_164216356.1 NZ_CP086102:c5222399-5222139 [Streptomyces anulatus]
VKFVWDQSSWDDYVWWQNQDRKVLKRINALLQDIARNGNEGMGKPEPLKHGFQGYWSRRITEEHRLIYKVVDDEVRVAAC
RYHYGR

Download         Length: 261 bp

>T222516 NZ_CP117959:c1488079-1486757 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9327.42 Da        Isoelectric Point: 4.5447

>AT222516 WP_050358889.1 NZ_CP086102:c5222647-5222396 [Streptomyces anulatus]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVRE
LAE

Download         Length: 252 bp

>AT222516 NZ_CP117959:c1488345-1488079 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C4HSG8

References