Detailed information of TA system TA222515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2901723..2902252
• Replicon: chromosome
• Accession: NZ_CP086102
• Organism: Streptomyces anulatus strain YINM00001

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LK895_RS12175
• Protein ID: WP_087765137.1
• Coordinates: 2901723..2901977 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LK895_RS12180
• Protein ID: WP_097910638.1
• Coordinates: 2901974..2902252 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK895_RS12170	2901147..2901506	-	360	WP_228181623.1	hypothetical protein	-
LK895_RS12175	2901723..2901977	-	255	WP_087765137.1	Txe/YoeB family addiction module toxin	Toxin
LK895_RS12180	2901974..2902252	-	279	WP_097910638.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LK895_RS12185	2902438..2903526	-	1089	WP_047178553.1	redox-regulated ATPase YchF	-
LK895_RS12190	2903928..2904509	+	582	WP_063780458.1	hypothetical protein	-
LK895_RS12195	2904776..2905528	-	753	WP_164220413.1	ROK family protein	-
LK895_RS12200	2905567..2906556	-	990	WP_178798256.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-64)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10092.59 Da
• Isoelectric Point: 9.3928

>T222515 WP_087765137.1 NZ_CP086102:c2901977-2901723 [Streptomyces anulatus]
VRLVFEDQGWEDYVSWLKNDRKILARINRLITDVKRDPFSGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDREIVILAA
RYHY

Nucleotide

• Length: 255 bp

>T222515 NZ_CP117959:1400928-1401104 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9874.12 Da
• Isoelectric Point: 5.1255

>AT222515 WP_097910638.1 NZ_CP086102:c2902252-2901974 [Streptomyces anulatus]
MSITASEARKGLFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGNINVSEREL
IDPDEGPAAGAA

Nucleotide

• Length: 279 bp

>AT222515 NZ_CP117959:1401150-1401566 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA