22249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3563497..3564167 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag TBFG_RS16855 Protein ID WP_003899954.1
Coordinates 3563497..3563841 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag TBFG_RS16860 Protein ID WP_003899955.1
Coordinates 3563838..3564167 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS16825 3558570..3559430 + 861 WP_003416628.1 alpha/beta hydrolase -
TBFG_RS16830 3559405..3559920 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
TBFG_RS16835 3560160..3560453 + 294 WP_003416635.1 hypothetical protein -
TBFG_RS16840 3560741..3562030 + 1290 WP_003906996.1 ATP-binding protein -
TBFG_RS16845 3562377..3562811 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
TBFG_RS16850 3562814..3563266 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TBFG_RS16855 3563497..3563841 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBFG_RS16860 3563838..3564167 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
TBFG_RS16875 3566063..3566410 + 348 WP_003899956.1 DUF2384 domain-containing protein -
TBFG_RS16880 3566407..3567027 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
TBFG_RS16885 3567187..3568452 - 1266 WP_003902423.1 hypothetical protein -
TBFG_RS16890 3568620..3568829 + 210 WP_003416778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T22249 WP_003899954.1 NC_009565:3563497-3563841 [Mycobacterium tuberculosis F11]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T22249 NC_009565:3563497-3563841 [Mycobacterium tuberculosis F11]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT22249 WP_003899955.1 NC_009565:3563838-3564167 [Mycobacterium tuberculosis F11]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT22249 NC_009565:3563838-3564167 [Mycobacterium tuberculosis F11]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
AlphaFold DB G0THF6

References