Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 763657..764179 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LKX03_RS04375 Protein ID WP_000221343.1
Coordinates 763895..764179 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LKX03_RS04370 Protein ID WP_000885424.1
Coordinates 763657..763905 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS04345 (758873) 758873..760339 + 1467 WP_000987828.1 hypothetical protein -
LKX03_RS04350 (761147) 761147..761861 + 715 Protein_771 helix-turn-helix domain-containing protein -
LKX03_RS04355 (761917) 761917..762825 - 909 WP_010989018.1 hypothetical protein -
LKX03_RS04360 (762968) 762968..763300 - 333 WP_000253154.1 DUF1493 family protein -
LKX03_RS04365 (763290) 763290..763505 - 216 WP_000206207.1 hypothetical protein -
LKX03_RS04370 (763657) 763657..763905 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LKX03_RS04375 (763895) 763895..764179 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LKX03_RS04380 (764350) 764350..764739 + 390 WP_000194089.1 RidA family protein -
LKX03_RS04385 (764791) 764791..765870 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LKX03_RS04390 (766063) 766063..766551 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
LKX03_RS04395 (766596) 766596..768104 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 758876..770961 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T222413 WP_000221343.1 NZ_CP085987:763895-764179 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T222413 NZ_CP117851:1202531-1202947 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTTGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGTCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT222413 WP_000885424.1 NZ_CP085987:763657-763905 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT222413 NZ_CP117851:1202304-1202534 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References