Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2988545..2989193 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TBFG_RS14100 Protein ID WP_003899414.1
Coordinates 2988545..2988868 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TBFG_RS14105 Protein ID WP_003899415.1
Coordinates 2988948..2989193 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS14070 2983868..2984866 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
TBFG_RS14075 2984880..2985344 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TBFG_RS14080 2985332..2985583 + 252 WP_003908028.1 hypothetical protein -
TBFG_RS14085 2985754..2987193 - 1440 WP_003899411.1 phage major capsid protein -
TBFG_RS14090 2987201..2987734 - 534 WP_003899412.1 HK97 family phage prohead protease -
TBFG_RS21610 2987887..2988378 - 492 WP_003900541.1 phage terminase small subunit P27 family -
TBFG_RS14100 2988545..2988868 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TBFG_RS14105 2988948..2989193 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TBFG_RS14110 2989190..2990617 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
TBFG_RS14115 2990619..2991011 - 393 WP_003899417.1 DUF2742 domain-containing protein -
TBFG_RS14120 2991008..2991268 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TBFG_RS14125 2991285..2991647 - 363 WP_003900543.1 hypothetical protein -
TBFG_RS14130 2991650..2992777 - 1128 WP_003899420.1 site-specific integrase -
TBFG_RS14135 2992922..2993149 - 228 WP_003899421.1 hypothetical protein -
TBFG_RS21615 2993146..2993535 - 390 WP_003899422.1 hypothetical protein -
TBFG_RS14140 2993441..2993713 + 273 WP_003900544.1 hypothetical protein -
TBFG_RS14145 2993812..2994045 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2983868..2992777 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(29-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T22241 WP_003899414.1 NC_009565:c2988868-2988545 [Mycobacterium tuberculosis F11]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T22241 NC_009565:c2988868-2988545 [Mycobacterium tuberculosis F11]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT22241 WP_003899415.1 NC_009565:c2989193-2988948 [Mycobacterium tuberculosis F11]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT22241 NC_009565:c2989193-2988948 [Mycobacterium tuberculosis F11]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References