Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 2988545..2989193 | Replicon | chromosome |
Accession | NC_009565 | ||
Organism | Mycobacterium tuberculosis F11 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | TBFG_RS14100 | Protein ID | WP_003899414.1 |
Coordinates | 2988545..2988868 (-) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | TBFG_RS14105 | Protein ID | WP_003899415.1 |
Coordinates | 2988948..2989193 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
TBFG_RS14070 | 2983868..2984866 | + | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
TBFG_RS14075 | 2984880..2985344 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
TBFG_RS14080 | 2985332..2985583 | + | 252 | WP_003908028.1 | hypothetical protein | - |
TBFG_RS14085 | 2985754..2987193 | - | 1440 | WP_003899411.1 | phage major capsid protein | - |
TBFG_RS14090 | 2987201..2987734 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
TBFG_RS21610 | 2987887..2988378 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
TBFG_RS14100 | 2988545..2988868 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
TBFG_RS14105 | 2988948..2989193 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
TBFG_RS14110 | 2989190..2990617 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
TBFG_RS14115 | 2990619..2991011 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
TBFG_RS14120 | 2991008..2991268 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
TBFG_RS14125 | 2991285..2991647 | - | 363 | WP_003900543.1 | hypothetical protein | - |
TBFG_RS14130 | 2991650..2992777 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
TBFG_RS14135 | 2992922..2993149 | - | 228 | WP_003899421.1 | hypothetical protein | - |
TBFG_RS21615 | 2993146..2993535 | - | 390 | WP_003899422.1 | hypothetical protein | - |
TBFG_RS14140 | 2993441..2993713 | + | 273 | WP_003900544.1 | hypothetical protein | - |
TBFG_RS14145 | 2993812..2994045 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2983868..2992777 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T22241 WP_003899414.1 NC_009565:c2988868-2988545 [Mycobacterium tuberculosis F11]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T22241 NC_009565:c2988868-2988545 [Mycobacterium tuberculosis F11]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT22241 WP_003899415.1 NC_009565:c2989193-2988948 [Mycobacterium tuberculosis F11]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT22241 NC_009565:c2989193-2988948 [Mycobacterium tuberculosis F11]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |