Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1871751..1872232 Replicon chromosome
Accession NZ_CP085970
Organism Bordetella pertussis strain FDAARGOS_1542

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LK412_RS08965 Protein ID WP_225975616.1
Coordinates 1872053..1872232 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LK412_RS08960 Protein ID WP_019247905.1
Coordinates 1871751..1872050 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK412_RS08950 (LK412_08950) 1867859..1868533 - 675 WP_010930489.1 response regulator transcription factor -
LK412_RS08955 (LK412_08955) 1868663..1871737 + 3075 WP_023995112.1 autotransporter SphB2 -
LK412_RS08960 (LK412_08960) 1871751..1872050 - 300 WP_019247905.1 NadS family protein Antitoxin
LK412_RS08965 (LK412_08965) 1872053..1872232 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LK412_RS08970 (LK412_08970) 1872365..1872988 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
LK412_RS08975 (LK412_08975) 1873232..1874101 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
LK412_RS08980 (LK412_08980) 1874079..1875023 - 945 WP_010930494.1 LysR family transcriptional regulator -
LK412_RS08985 (LK412_08985) 1875109..1876131 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
LK412_RS08990 (LK412_08990) 1876148..1876921 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T222333 WP_225975616.1 NZ_CP085970:c1872232-1872053 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T222333 NZ_CP117817:c1124434-1123928 [Legionella pneumophila]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT222333 WP_019247905.1 NZ_CP085970:c1872050-1871751 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT222333 NZ_CP117817:c1124781-1124434 [Legionella pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References