Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 496107..496762 | Replicon | chromosome |
| Accession | NZ_CP085969 | ||
| Organism | Bordetella pertussis strain FDAARGOS_1543 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | - |
| Locus tag | LK428_RS02350 | Protein ID | WP_047122780.1 |
| Coordinates | 496107..496358 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | Q7VY40 |
| Locus tag | LK428_RS02355 | Protein ID | WP_003809516.1 |
| Coordinates | 496361..496762 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK428_RS02325 (LK428_02325) | 491267..492397 | - | 1131 | WP_010930401.1 | helix-turn-helix transcriptional regulator | - |
| LK428_RS02330 (LK428_02330) | 492632..493213 | + | 582 | WP_019247931.1 | MOSC domain-containing protein | - |
| LK428_RS02335 (LK428_02335) | 493350..494414 | + | 1065 | WP_003809510.1 | fructose-bisphosphate aldolase class II | - |
| LK428_RS02340 (LK428_02340) | 494499..494945 | - | 447 | WP_003819827.1 | GFA family protein | - |
| LK428_RS02345 (LK428_02345) | 495171..496052 | + | 882 | WP_003809513.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| LK428_RS02350 (LK428_02350) | 496107..496358 | + | 252 | WP_047122780.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| LK428_RS02355 (LK428_02355) | 496361..496762 | + | 402 | WP_003809516.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| LK428_RS02360 (LK428_02360) | 496782..497018 | + | 237 | WP_010930404.1 | DUF5993 family protein | - |
| LK428_RS02365 (LK428_02365) | 497026..497505 | + | 480 | WP_010930405.1 | disulfide bond formation protein B | - |
| LK428_RS02370 (LK428_02370) | 497655..498170 | + | 516 | WP_019247930.1 | 5-(carboxyamino)imidazole ribonucleotide mutase | - |
| LK428_RS02375 (LK428_02375) | 498173..499363 | + | 1191 | WP_014905781.1 | 5-(carboxyamino)imidazole ribonucleotide synthase | - |
| LK428_RS02380 (LK428_02380) | 499383..500420 | + | 1038 | WP_023853543.1 | L-threonylcarbamoyladenylate synthase | - |
| LK428_RS02385 (LK428_02385) | 500557..501579 | + | 1023 | WP_003809532.1 | amino acid ABC transporter substrate-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 8952.52 Da Isoelectric Point: 9.7242
>T222329 WP_047122780.1 NZ_CP085969:496107-496358 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL
Download Length: 252 bp
>T222329 NZ_CP117814:c1161854-1161348 [Legionella pneumophila]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14528.70 Da Isoelectric Point: 8.5005
>AT222329 WP_003809516.1 NZ_CP085969:496361-496762 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD
Download Length: 402 bp
>AT222329 NZ_CP117814:c1162201-1161854 [Legionella pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|