Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 407982..408651 Replicon chromosome
Accession NZ_CP085952
Organism Haemophilus influenzae strain FDAARGOS_1560

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag LK401_RS02080 Protein ID WP_015701504.1
Coordinates 408268..408651 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag LK401_RS02075 Protein ID WP_005651224.1
Coordinates 407982..408284 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK401_RS02055 (LK401_02055) 403695..403853 - 159 WP_005651234.1 hypothetical protein -
LK401_RS02060 (LK401_02060) 403945..404277 - 333 WP_038440713.1 phage tail protein -
LK401_RS02065 (LK401_02065) 404286..407678 - 3393 WP_058222179.1 tape measure protein -
LK401_RS02070 (LK401_02070) 407730..407966 - 237 WP_101494098.1 hypothetical protein -
LK401_RS02075 (LK401_02075) 407982..408284 - 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
LK401_RS02080 (LK401_02080) 408268..408651 - 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LK401_RS02085 (LK401_02085) 408720..408947 - 228 WP_058222178.1 DUF4035 domain-containing protein -
LK401_RS02090 (LK401_02090) 408992..409399 - 408 WP_038440705.1 hypothetical protein -
LK401_RS02095 (LK401_02095) 409674..410324 - 651 WP_050846007.1 hypothetical protein -
LK401_RS02100 (LK401_02100) 410327..410698 - 372 WP_238595237.1 phage minor tail U family protein -
LK401_RS02105 (LK401_02105) 410746..411276 - 531 WP_015701508.1 phage tail protein -
LK401_RS02110 (LK401_02110) 411279..411590 - 312 WP_015701509.1 hypothetical protein -
LK401_RS02115 (LK401_02115) 411571..411894 - 324 WP_015701510.1 DUF2190 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 392001..445188 53187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T222306 WP_015701504.1 NZ_CP085952:c408651-408268 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T222306 NZ_CP117768:c2917241-2916855 [Nostoc sp. UHCC 0926]
ATGAAACTATTATTAGATACCCATATTTTCTTATGGTTTATTAGTGGTGATCAAAAATTACCAATTAATTTACAAAATAG
CATTCGTGATTTAAATAACGATGTATATTTAAGTTGCGTTTCAGTTTGGGAAGCAACTGTTAAATATCAATTAGGTAAAT
TACCATTACCAGAATCACCTGAAATCTATCTTCCTAAACAGCGTCAGCAGCATTTAATCAGTAGTCTCAACCTAGATGAA
GAAAGTGTTGCTCAACTATTAAAATTACCATTATTACATCGCGATCCTTTTGATAGGATGTTGATTTGTCAAGCTTTACA
ACATAATTTAACAATTTTAACTGTAGACCCGGCAATTCGTTCCTACTCGGTCAGTGTTTTATATTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT222306 WP_005651224.1 NZ_CP085952:c408284-407982 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT222306 NZ_CP117768:c2917477-2917238 [Nostoc sp. UHCC 0926]
ATGTTAACCGTAACAATTGATGAAATCCAGCAGAACTTAACTAGCTATCTTCAACAAGTAGTAGCAGGAGAAAGTATTAT
TATCATGCAAGCAGGTAAACCTATTGCAGAAATTAAACCAGTTTCAGCCACCTCTCAACCAATTAGACCTTATGGCTTAT
GTGCTGGGGAGTTCATTGTTCCAGATGATTTTGATAGTCCCTTACCTGAAGAGATTTTGAATAGTTTTGAAGGGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References