Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 115401..116128 | Replicon | plasmid pFK8695-rmpA |
| Accession | NZ_CP085891 | ||
| Organism | Klebsiella pneumoniae strain 8695 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | LKW25_RS28670 | Protein ID | WP_011251285.1 |
| Coordinates | 115817..116128 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LKW25_RS28665 | Protein ID | WP_011251286.1 |
| Coordinates | 115401..115820 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LKW25_RS28635 (LKW25_28635) | 110569..111039 | - | 471 | WP_048333570.1 | hypothetical protein | - |
| LKW25_RS28640 (LKW25_28640) | 111352..111987 | - | 636 | WP_223171879.1 | hypothetical protein | - |
| LKW25_RS28645 (LKW25_28645) | 112406..113026 | + | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| LKW25_RS28650 (LKW25_28650) | 113047..113835 | + | 789 | WP_040217257.1 | hypothetical protein | - |
| LKW25_RS28655 (LKW25_28655) | 113849..114214 | + | 366 | WP_048333448.1 | hypothetical protein | - |
| LKW25_RS28660 (LKW25_28660) | 114286..115254 | - | 969 | WP_074428168.1 | IS5 family transposase | - |
| LKW25_RS28665 (LKW25_28665) | 115401..115820 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LKW25_RS28670 (LKW25_28670) | 115817..116128 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LKW25_RS28675 (LKW25_28675) | 116333..116770 | - | 438 | Protein_126 | DDE-type integrase/transposase/recombinase | - |
| LKW25_RS28680 (LKW25_28680) | 116905..117602 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
| LKW25_RS28685 (LKW25_28685) | 117604..118053 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| LKW25_RS28690 (LKW25_28690) | 118070..118381 | + | 312 | WP_011251282.1 | hypothetical protein | - |
| LKW25_RS28695 (LKW25_28695) | 118395..118736 | + | 342 | WP_011251281.1 | hypothetical protein | - |
| LKW25_RS28700 (LKW25_28700) | 118796..119752 | + | 957 | WP_011251280.1 | DsbA family protein | - |
| LKW25_RS28705 (LKW25_28705) | 120177..120617 | - | 441 | WP_011251275.1 | hypothetical protein | - |
| LKW25_RS28710 (LKW25_28710) | 120623..121117 | - | 495 | WP_011251274.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | iroN / rmpA / rmpA | 1..150052 | 150052 | |
| - | inside | IScluster/Tn | - | - | 98730..123037 | 24307 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T222263 WP_011251285.1 NZ_CP085891:c116128-115817 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T222263 NZ_CP117745:1472858-1473340 [Klebsiella pneumoniae]
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT222263 WP_011251286.1 NZ_CP085891:c115820-115401 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT222263 NZ_CP117745:1472604-1472870 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCTTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCTTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|