Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3034625..3035318 Replicon chromosome
Accession NZ_CP085842
Organism Escherichia coli strain B95. delta A

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LJ838_RS14835 Protein ID WP_000415584.1
Coordinates 3035022..3035318 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LJ838_RS14830 Protein ID WP_000650107.1
Coordinates 3034625..3035020 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ838_RS14820 (3030489) 3030489..3032747 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
LJ838_RS14825 (3032885) 3032885..3034492 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LJ838_RS14830 (3034625) 3034625..3035020 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LJ838_RS14835 (3035022) 3035022..3035318 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LJ838_RS14840 (3035523) 3035523..3036005 - 483 WP_000183505.1 GyrI-like domain-containing protein -
LJ838_RS14845 (3036058) 3036058..3036450 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LJ838_RS14850 (3036602) 3036602..3037261 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LJ838_RS14855 (3037258) 3037258..3038607 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LJ838_RS14860 (3038653) 3038653..3038985 - 333 WP_000917684.1 DUF2645 family protein -
LJ838_RS14865 (3039304) 3039304..3039885 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
LJ838_RS14870 (3039916) 3039916..3040230 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T222157 WP_000415584.1 NZ_CP085842:c3035318-3035022 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T222157 NZ_CP117714:2726719-2726826 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT222157 WP_000650107.1 NZ_CP085842:c3035020-3034625 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT222157 NZ_CP117714:c2726672-2726606 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References