Detailed information of TA system TA222123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2790771..2791042
• Replicon: chromosome
• Accession: NZ_CP085841
• Organism: Enterococcus faecalis strain FA2-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: LJ570_RS13625
• Protein ID: WP_073340360.1
• Coordinates: 2790771..2790911 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2790844..2791042 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJ570_RS13605	2786039..2787031	+	993	WP_002385136.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LJ570_RS13610	2787295..2787933	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LJ570_RS13615	2788621..2790237	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
LJ570_RS13620	2790455..2790652	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	-
LJ570_RS13625	2790771..2790911	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2790844..2791042	-	199	-	-	Antitoxin
LJ570_RS13630	2791205..2791348	+	144	WP_002388634.1	putative holin-like toxin	-
LJ570_RS13635	2791543..2795418	-	3876	Protein_2660	WxL domain-containing protein	-
LJ570_RS13640	2795399..2795767	-	369	WP_002388636.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T222123 WP_073340360.1 NZ_CP085841:2790771-2790911 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T222123 NZ_CP117696:c4187101-4186610 [Salmonella enterica subsp. enterica serovar London]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT222123 NZ_CP085841:c2791042-2790844 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGA
CGGTGACCAATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAAACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin