Detailed information of TA system TA222089

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2795426..2795651
• Replicon: chromosome
• Accession: NZ_CP085824
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF36_RS13570
• Protein ID: WP_000813254.1
• Coordinates: 2795426..2795581 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2795593..2795651 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF36_RS13535	2790533..2790814	-	282	WP_000445513.1	phage holin family protein	-
LJF36_RS13540	2790804..2790992	-	189	WP_001688615.1	putative holin	-
LJF36_RS13545	2790986..2791309	-	324	Protein_2632	tellurite/colicin resistance protein	-
LJF36_RS13550	2793480..2794016	-	537	WP_000640113.1	DUF1133 family protein	-
LJF36_RS13555	2794013..2794303	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF36_RS13560	2794303..2794902	-	600	WP_000940751.1	DUF1367 family protein	-
LJF36_RS13565	2794965..2795135	-	171	WP_000734094.1	hypothetical protein	-
LJF36_RS13570	2795426..2795581	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2795593..2795651	+	59	-	-	Antitoxin
LJF36_RS13575	2796008..2796940	+	933	WP_000556390.1	hypothetical protein	-
LJF36_RS13580	2796937..2797491	+	555	WP_001033796.1	hypothetical protein	-
LJF36_RS13585	2797653..2797982	-	330	WP_001676916.1	DUF977 family protein	-
LJF36_RS22770	2798026..2798073	-	48	Protein_2641	hypothetical protein	-
LJF36_RS13595	2798255..2798722	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF36_RS13600	2799107..2799262	+	156	WP_085981757.1	DUF1391 family protein	-
LJF36_RS13605	2799370..2799891	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF36_RS13610	2800329..2800550	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2789991..2799891	9900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T222089 WP_000813254.1 NZ_CP085824:c2795581-2795426 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T222089 NZ_CP117678:2783532-2783834 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT222089 NZ_CP085824:2795593-2795651 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin