Detailed information of TA system TA222072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2944808..2945410
• Replicon: chromosome
• Accession: NZ_CP085823
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LJF47_RS14495
• Protein ID: WP_001159635.1
• Coordinates: 2944808..2945119 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJF47_RS14500
• Protein ID: WP_000362050.1
• Coordinates: 2945120..2945410 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF47_RS14460 (2939921)	2939921..2940520	+	600	WP_000965695.1	glucose-1-phosphatase	-
LJF47_RS14465 (2940514)	2940514..2941386	+	873	WP_000921423.1	virulence factor BrkB family protein	-
LJF47_RS14470 (2941383)	2941383..2941820	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LJF47_RS14475 (2941865)	2941865..2942806	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJF47_RS14480 (2942821)	2942821..2943267	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LJF47_RS14485 (2943264)	2943264..2943575	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LJF47_RS14490 (2943661)	2943661..2944590	-	930	WP_001127705.1	alpha/beta hydrolase	-
LJF47_RS14495 (2944808)	2944808..2945119	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJF47_RS14500 (2945120)	2945120..2945410	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJF47_RS14505 (2945457)	2945457..2946386	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LJF47_RS14510 (2946383)	2946383..2947018	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJF47_RS14515 (2947015)	2947015..2947917	-	903	WP_227803732.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T222072 WP_001159635.1 NZ_CP085823:2944808-2945119 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T222072 NZ_CP117672:2001728-2001831 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT222072 WP_000362050.1 NZ_CP085823:2945120-2945410 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT222072 NZ_CP117672:c2001869-2001598 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A3V2JK97