Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2942821..2943575 Replicon chromosome
Accession NZ_CP085823
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF47_RS14485 Protein ID WP_000558168.1
Coordinates 2943264..2943575 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF47_RS14480 Protein ID WP_001259009.1
Coordinates 2942821..2943267 (-) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF47_RS14450 (2937997) 2937997..2938893 + 897 WP_001520529.1 sugar kinase -
LJF47_RS14455 (2938927) 2938927..2939730 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF47_RS14460 (2939921) 2939921..2940520 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF47_RS14465 (2940514) 2940514..2941386 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF47_RS14470 (2941383) 2941383..2941820 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF47_RS14475 (2941865) 2941865..2942806 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF47_RS14480 (2942821) 2942821..2943267 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF47_RS14485 (2943264) 2943264..2943575 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF47_RS14490 (2943661) 2943661..2944590 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF47_RS14495 (2944808) 2944808..2945119 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF47_RS14500 (2945120) 2945120..2945410 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF47_RS14505 (2945457) 2945457..2946386 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF47_RS14510 (2946383) 2946383..2947018 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF47_RS14515 (2947015) 2947015..2947917 - 903 WP_227803732.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T222071 WP_000558168.1 NZ_CP085823:c2943575-2943264 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T222071 NZ_CP117672:1807388-1807642 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT222071 WP_001259009.1 NZ_CP085823:c2943267-2942821 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT222071 NZ_CP117672:1807140-1807391 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1R2S541


Antitoxin

Source ID Structure

References