Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3324801..3325555 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF58_RS16250 Protein ID WP_000558168.1
Coordinates 3324801..3325112 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF58_RS16255 Protein ID WP_001259009.1
Coordinates 3325109..3325555 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS16220 (3320459) 3320459..3321361 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF58_RS16225 (3321358) 3321358..3321993 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF58_RS16230 (3321990) 3321990..3322919 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF58_RS16235 (3322966) 3322966..3323256 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF58_RS16240 (3323257) 3323257..3323568 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF58_RS16245 (3323786) 3323786..3324715 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF58_RS16250 (3324801) 3324801..3325112 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF58_RS16255 (3325109) 3325109..3325555 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF58_RS16260 (3325570) 3325570..3326511 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF58_RS16265 (3326556) 3326556..3326993 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF58_RS16270 (3326990) 3326990..3327862 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF58_RS16275 (3327856) 3327856..3328455 - 600 WP_000965695.1 glucose-1-phosphatase -
LJF58_RS16280 (3328646) 3328646..3329449 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF58_RS16285 (3329483) 3329483..3330379 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T222048 WP_000558168.1 NZ_CP085822:3324801-3325112 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T222048 NZ_CP117668:c1156371-1156216 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGACCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT222048 WP_001259009.1 NZ_CP085822:3325109-3325555 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT222048 NZ_CP117668:1156383-1156441 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References