Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3322966..3323568 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag LJF58_RS16240 Protein ID WP_001159635.1
Coordinates 3323257..3323568 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF58_RS16235 Protein ID WP_000362050.1
Coordinates 3322966..3323256 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS16220 (3320459) 3320459..3321361 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF58_RS16225 (3321358) 3321358..3321993 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF58_RS16230 (3321990) 3321990..3322919 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF58_RS16235 (3322966) 3322966..3323256 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF58_RS16240 (3323257) 3323257..3323568 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF58_RS16245 (3323786) 3323786..3324715 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF58_RS16250 (3324801) 3324801..3325112 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
LJF58_RS16255 (3325109) 3325109..3325555 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF58_RS16260 (3325570) 3325570..3326511 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF58_RS16265 (3326556) 3326556..3326993 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF58_RS16270 (3326990) 3326990..3327862 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF58_RS16275 (3327856) 3327856..3328455 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T222047 WP_001159635.1 NZ_CP085822:c3323568-3323257 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T222047 NZ_CP117668:c1014226-1014124 [Escherichia albertii]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT222047 WP_000362050.1 NZ_CP085822:c3323256-3322966 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT222047 NZ_CP117668:1014122-1014354 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References