Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1337515..1338053 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LJF64_RS06500 Protein ID WP_001526148.1
Coordinates 1337515..1337790 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LJF64_RS06505 Protein ID WP_000729713.1
Coordinates 1337793..1338053 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS06495 (1334722) 1334722..1337427 + 2706 WP_080076139.1 HTH-type transcriptional regulator MalT -
LJF64_RS06500 (1337515) 1337515..1337790 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJF64_RS06505 (1337793) 1337793..1338053 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF64_RS06510 (1338162) 1338162..1339181 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
LJF64_RS06515 (1339185) 1339185..1340399 - 1215 WP_001105521.1 RNA-splicing ligase RtcB -
LJF64_RS06520 (1340747) 1340747..1342301 - 1555 Protein_1271 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T221983 WP_001526148.1 NZ_CP085820:c1337790-1337515 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221983 NZ_CP117648:51956-52126 [Escherichia albertii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTTTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAGTGCGACAAGAAGTCGTCCAACA
TATTGTTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT221983 WP_000729713.1 NZ_CP085820:c1338053-1337793 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221983 NZ_CP117648:c51912-51851 [Escherichia albertii]
TTGAGATACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References