221979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4358374..4358896 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LJF65_RS21010 Protein ID WP_000221343.1
Coordinates 4358612..4358896 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LJF65_RS21005 Protein ID WP_000885424.1
Coordinates 4358374..4358622 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS20980 (4353590) 4353590..4355056 + 1467 WP_000987828.1 hypothetical protein -
LJF65_RS20985 (4355864) 4355864..4356578 + 715 Protein_4085 helix-turn-helix domain-containing protein -
LJF65_RS20990 (4356634) 4356634..4357542 - 909 WP_077918335.1 hypothetical protein -
LJF65_RS20995 (4357685) 4357685..4358017 - 333 WP_000253154.1 DUF1493 family protein -
LJF65_RS21000 (4358007) 4358007..4358222 - 216 WP_000206207.1 hypothetical protein -
LJF65_RS21005 (4358374) 4358374..4358622 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF65_RS21010 (4358612) 4358612..4358896 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF65_RS21015 (4359067) 4359067..4359456 + 390 WP_000194089.1 RidA family protein -
LJF65_RS21020 (4359508) 4359508..4360587 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LJF65_RS21025 (4360780) 4360780..4361268 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
LJF65_RS21030 (4361313) 4361313..4362821 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4353593..4365678 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T221979 WP_000221343.1 NZ_CP085819:4358612-4358896 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T221979 NZ_CP117647:3975941-3976093 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT221979 WP_000885424.1 NZ_CP085819:4358374-4358622 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT221979 NZ_CP117647:c3975892-3975835 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References