Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2259385..2259923 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LJF65_RS10560 Protein ID WP_001526148.1
Coordinates 2259648..2259923 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LJF65_RS10555 Protein ID WP_000729713.1
Coordinates 2259385..2259645 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS10540 (2255137) 2255137..2256691 + 1555 Protein_2043 TROVE domain-containing protein -
LJF65_RS10545 (2257039) 2257039..2258253 + 1215 WP_001105521.1 RNA-splicing ligase RtcB -
LJF65_RS10550 (2258257) 2258257..2259276 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
LJF65_RS10555 (2259385) 2259385..2259645 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF65_RS10560 (2259648) 2259648..2259923 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJF65_RS10565 (2260011) 2260011..2262716 - 2706 WP_080076139.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T221967 WP_001526148.1 NZ_CP085819:2259648-2259923 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221967 NZ_CP117647:182041-182193 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTACATATTAAGCAGGGAAGTAATGAGCTGGCGACATTTTTAGCCTGTGGAAATAAAAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT221967 WP_000729713.1 NZ_CP085819:2259385-2259645 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221967 NZ_CP117647:c181990-181936 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References