Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1699345..1700099 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LJF65_RS07955 Protein ID WP_000558166.1
Coordinates 1699345..1699656 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF65_RS07960 Protein ID WP_001259011.1
Coordinates 1699653..1700099 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS07925 (1695003) 1695003..1695905 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LJF65_RS07930 (1695902) 1695902..1696537 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF65_RS07935 (1696534) 1696534..1697463 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LJF65_RS07940 (1697510) 1697510..1697800 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF65_RS07945 (1697801) 1697801..1698112 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF65_RS07950 (1698330) 1698330..1699259 + 930 WP_001127703.1 alpha/beta hydrolase -
LJF65_RS07955 (1699345) 1699345..1699656 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF65_RS07960 (1699653) 1699653..1700099 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF65_RS07965 (1700114) 1700114..1701055 - 942 WP_227761035.1 fatty acid biosynthesis protein FabY -
LJF65_RS07970 (1701100) 1701100..1701537 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LJF65_RS07975 (1701534) 1701534..1702406 - 873 WP_000921427.1 virulence factor BrkB family protein -
LJF65_RS07980 (1702400) 1702400..1702999 - 600 WP_000965695.1 glucose-1-phosphatase -
LJF65_RS07985 (1703190) 1703190..1703993 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF65_RS07990 (1704027) 1704027..1704923 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T221964 WP_000558166.1 NZ_CP085819:1699345-1699656 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T221964 NZ_CP117644:89532-89681 [Escherichia albertii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT221964 WP_001259011.1 NZ_CP085819:1699653-1700099 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221964 NZ_CP117644:c89488-89440 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References