221953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4207550..4208088 Replicon chromosome
Accession NZ_CP085818
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LJF66_RS20635 Protein ID WP_001526148.1
Coordinates 4207550..4207825 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LJF66_RS20640 Protein ID WP_000729713.1
Coordinates 4207828..4208088 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF66_RS20630 (4204757) 4204757..4207462 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
LJF66_RS20635 (4207550) 4207550..4207825 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJF66_RS20640 (4207828) 4207828..4208088 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF66_RS20645 (4208197) 4208197..4209216 - 1020 WP_000101024.1 RNA 3'-terminal phosphate cyclase -
LJF66_RS20650 (4209220) 4209220..4210434 - 1215 WP_001105533.1 RNA-splicing ligase RtcB -
LJF66_RS20655 (4210782) 4210782..4212335 - 1554 WP_000013013.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T221953 WP_001526148.1 NZ_CP085818:c4207825-4207550 [Salmonella enterica subsp. enterica serovar Enteritidis]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221953 NZ_CP117643:1071780-1071932 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT221953 WP_000729713.1 NZ_CP085818:c4208088-4207828 [Salmonella enterica subsp. enterica serovar Enteritidis]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221953 NZ_CP117643:c1071738-1071686 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References