Detailed information of TA system TA221948

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2091179..2091404
• Replicon: chromosome
• Accession: NZ_CP085818
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF66_RS10145
• Protein ID: WP_000813254.1
• Coordinates: 2091249..2091404 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2091179..2091237 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF66_RS10105	2086280..2086501	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF66_RS10110	2086939..2087460	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF66_RS10115	2087568..2087723	-	156	WP_085981757.1	DUF1391 family protein	-
LJF66_RS10120	2088108..2088575	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF66_RS22985	2088757..2088804	+	48	Protein_1961	hypothetical protein	-
LJF66_RS10130	2088848..2089177	+	330	WP_001676916.1	DUF977 family protein	-
LJF66_RS10135	2089339..2089893	-	555	WP_001033796.1	hypothetical protein	-
LJF66_RS10140	2089890..2090822	-	933	WP_000556390.1	hypothetical protein	-
-	2091179..2091237	-	59	-	-	Antitoxin
LJF66_RS10145	2091249..2091404	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF66_RS10150	2091695..2091865	+	171	WP_000734094.1	hypothetical protein	-
LJF66_RS10155	2091928..2092527	+	600	WP_000940751.1	DUF1367 family protein	-
LJF66_RS10160	2092527..2092817	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF66_RS10165	2092814..2093350	+	537	WP_000640113.1	DUF1133 family protein	-
LJF66_RS10170	2095521..2095844	+	324	Protein_1970	tellurite/colicin resistance protein	-
LJF66_RS10175	2095838..2096026	+	189	WP_001688615.1	putative holin	-
LJF66_RS10180	2096016..2096297	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2084968..2096839	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221948 WP_000813254.1 NZ_CP085818:2091249-2091404 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221948 NZ_CP117639:34686-35066 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT221948 NZ_CP085818:c2091237-2091179 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin