221930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 43857..44611 Replicon chromosome
Accession NZ_CP085818
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF66_RS00215 Protein ID WP_000558168.1
Coordinates 44300..44611 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF66_RS00210 Protein ID WP_001259009.1
Coordinates 43857..44303 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF66_RS00180 (39033) 39033..39929 + 897 WP_001520529.1 sugar kinase -
LJF66_RS00185 (39963) 39963..40766 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF66_RS00190 (40957) 40957..41556 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF66_RS00195 (41550) 41550..42422 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF66_RS00200 (42419) 42419..42856 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF66_RS00205 (42901) 42901..43842 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF66_RS00210 (43857) 43857..44303 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF66_RS00215 (44300) 44300..44611 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF66_RS00220 (44697) 44697..45626 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF66_RS00225 (45844) 45844..46155 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF66_RS00230 (46156) 46156..46446 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF66_RS00235 (46493) 46493..47422 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF66_RS00240 (47419) 47419..48054 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF66_RS00245 (48051) 48051..48953 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T221930 WP_000558168.1 NZ_CP085818:c44611-44300 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T221930 NZ_CP117632:41129-41281 [Escherichia albertii]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT221930 WP_001259009.1 NZ_CP085818:c44303-43857 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221930 NZ_CP117632:c41079-41017 [Escherichia albertii]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References