Detailed information of TA system TA221925

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2706786..2707011
• Replicon: chromosome
• Accession: NZ_CP085817
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF67_RS13075
• Protein ID: WP_000813254.1
• Coordinates: 2706856..2707011 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2706786..2706844 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF67_RS13035	2701887..2702108	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF67_RS13040	2702546..2703067	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF67_RS13045	2703175..2703330	-	156	WP_085981757.1	DUF1391 family protein	-
LJF67_RS13050	2703715..2704182	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF67_RS23015	2704364..2704411	+	48	Protein_2531	hypothetical protein	-
LJF67_RS13060	2704455..2704784	+	330	WP_001676916.1	DUF977 family protein	-
LJF67_RS13065	2704946..2705500	-	555	WP_001033796.1	hypothetical protein	-
LJF67_RS13070	2705497..2706429	-	933	WP_000556390.1	hypothetical protein	-
-	2706786..2706844	-	59	-	-	Antitoxin
LJF67_RS13075	2706856..2707011	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF67_RS13080	2707302..2707472	+	171	WP_000734094.1	hypothetical protein	-
LJF67_RS13085	2707535..2708134	+	600	WP_000940751.1	DUF1367 family protein	-
LJF67_RS13090	2708134..2708424	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF67_RS13095	2708421..2708957	+	537	WP_000640113.1	DUF1133 family protein	-
LJF67_RS13100	2711128..2711451	+	324	Protein_2540	tellurite/colicin resistance protein	-
LJF67_RS13105	2711445..2711633	+	189	WP_001688615.1	putative holin	-
LJF67_RS13110	2711623..2711904	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2700575..2712446	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221925 WP_000813254.1 NZ_CP085817:2706856-2707011 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221925 NZ_CP117629:25754-26035 [Escherichia albertii]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAAGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGTCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGATTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGCGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221925 NZ_CP085817:c2706844-2706786 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin