Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 661635..662237 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag LJF67_RS03155 Protein ID WP_001159635.1
Coordinates 661635..661946 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF67_RS03160 Protein ID WP_000362050.1
Coordinates 661947..662237 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS03120 (656748) 656748..657347 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF67_RS03125 (657341) 657341..658213 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF67_RS03130 (658210) 658210..658647 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF67_RS03135 (658692) 658692..659633 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF67_RS03140 (659648) 659648..660094 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF67_RS03145 (660091) 660091..660402 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
LJF67_RS03150 (660488) 660488..661417 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF67_RS03155 (661635) 661635..661946 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF67_RS03160 (661947) 661947..662237 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF67_RS03165 (662284) 662284..663213 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF67_RS03170 (663210) 663210..663845 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF67_RS03175 (663842) 663842..664744 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T221908 WP_001159635.1 NZ_CP085817:661635-661946 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221908 NZ_CP117620:c4466999-4466847 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221908 WP_000362050.1 NZ_CP085817:661947-662237 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221908 NZ_CP117620:4467056-4467104 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References