Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 659648..660402 | Replicon | chromosome |
| Accession | NZ_CP085817 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | LJF67_RS03145 | Protein ID | WP_000558168.1 |
| Coordinates | 660091..660402 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF67_RS03140 | Protein ID | WP_001259009.1 |
| Coordinates | 659648..660094 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF67_RS03110 (654824) | 654824..655720 | + | 897 | WP_001520529.1 | sugar kinase | - |
| LJF67_RS03115 (655754) | 655754..656557 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LJF67_RS03120 (656748) | 656748..657347 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF67_RS03125 (657341) | 657341..658213 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF67_RS03130 (658210) | 658210..658647 | + | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| LJF67_RS03135 (658692) | 658692..659633 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF67_RS03140 (659648) | 659648..660094 | - | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF67_RS03145 (660091) | 660091..660402 | - | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF67_RS03150 (660488) | 660488..661417 | - | 930 | WP_001127705.1 | alpha/beta hydrolase | - |
| LJF67_RS03155 (661635) | 661635..661946 | + | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LJF67_RS03160 (661947) | 661947..662237 | + | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LJF67_RS03165 (662284) | 662284..663213 | - | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF67_RS03170 (663210) | 663210..663845 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF67_RS03175 (663842) | 663842..664744 | - | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T221907 WP_000558168.1 NZ_CP085817:c660402-660091 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T221907 NZ_CP117620:4383804-4384106 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAACGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGCTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAACGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGCTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221907 WP_001259009.1 NZ_CP085817:c660094-659648 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221907 NZ_CP117620:4384178-4384516 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|