Detailed information of TA system TA221899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4056655..4057257
• Replicon: chromosome
• Accession: NZ_CP085816
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LJF68_RS19865
• Protein ID: WP_001159635.1
• Coordinates: 4056946..4057257 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJF68_RS19860
• Protein ID: WP_000362050.1
• Coordinates: 4056655..4056945 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF68_RS19845 (4054148)	4054148..4055050	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LJF68_RS19850 (4055047)	4055047..4055682	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJF68_RS19855 (4055679)	4055679..4056608	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LJF68_RS19860 (4056655)	4056655..4056945	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJF68_RS19865 (4056946)	4056946..4057257	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJF68_RS19870 (4057475)	4057475..4058404	+	930	WP_001127705.1	alpha/beta hydrolase	-
LJF68_RS19875 (4058490)	4058490..4058801	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LJF68_RS19880 (4058798)	4058798..4059244	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LJF68_RS19885 (4059259)	4059259..4060200	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJF68_RS19890 (4060245)	4060245..4060682	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LJF68_RS19895 (4060679)	4060679..4061551	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LJF68_RS19900 (4061545)	4061545..4062144	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T221899 WP_001159635.1 NZ_CP085816:c4057257-4056946 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T221899 NZ_CP117620:c2201077-2200799 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTAATTGATGCCGCAAGCAGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT221899 WP_000362050.1 NZ_CP085816:c4056945-4056655 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT221899 NZ_CP117620:c2200799-2200515 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTAACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97