Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3324885..3325639 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF37_RS16260 Protein ID WP_000558168.1
Coordinates 3324885..3325196 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF37_RS16265 Protein ID WP_001259009.1
Coordinates 3325193..3325639 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS16230 (3320543) 3320543..3321445 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF37_RS16235 (3321442) 3321442..3322077 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF37_RS16240 (3322074) 3322074..3323003 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF37_RS16245 (3323050) 3323050..3323340 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF37_RS16250 (3323341) 3323341..3323652 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF37_RS16255 (3323870) 3323870..3324799 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF37_RS16260 (3324885) 3324885..3325196 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF37_RS16265 (3325193) 3325193..3325639 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF37_RS16270 (3325654) 3325654..3326595 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF37_RS16275 (3326640) 3326640..3327077 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF37_RS16280 (3327074) 3327074..3327946 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF37_RS16285 (3327940) 3327940..3328539 - 600 WP_000965695.1 glucose-1-phosphatase -
LJF37_RS16290 (3328730) 3328730..3329533 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF37_RS16295 (3329567) 3329567..3330463 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T221871 WP_000558168.1 NZ_CP085815:3324885-3325196 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T221871 NZ_CP117611:65833-65982 [Escherichia albertii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT221871 WP_001259009.1 NZ_CP085815:3325193-3325639 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221871 NZ_CP117611:c65789-65728 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References