Detailed information of TA system TA221853

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1278287..1278512
• Replicon: chromosome
• Accession: NZ_CP085815
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF37_RS06320
• Protein ID: WP_000813254.1
• Coordinates: 1278287..1278442 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1278454..1278512 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF37_RS06285	1273394..1273675	-	282	WP_000445513.1	phage holin family protein	-
LJF37_RS06290	1273665..1273853	-	189	WP_001688615.1	putative holin	-
LJF37_RS06295	1273847..1274170	-	324	Protein_1235	tellurite/colicin resistance protein	-
LJF37_RS06300	1276341..1276877	-	537	WP_000640113.1	DUF1133 family protein	-
LJF37_RS06305	1276874..1277164	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF37_RS06310	1277164..1277763	-	600	WP_000940751.1	DUF1367 family protein	-
LJF37_RS06315	1277826..1277996	-	171	WP_000734094.1	hypothetical protein	-
LJF37_RS06320	1278287..1278442	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1278454..1278512	+	59	-	-	Antitoxin
LJF37_RS06325	1278869..1279801	+	933	WP_000556390.1	hypothetical protein	-
LJF37_RS06330	1279798..1280352	+	555	WP_001033796.1	hypothetical protein	-
LJF37_RS06335	1280514..1280843	-	330	WP_001676916.1	DUF977 family protein	-
LJF37_RS23010	1280887..1280934	-	48	Protein_1244	hypothetical protein	-
LJF37_RS06345	1281116..1281583	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF37_RS06350	1281968..1282123	+	156	WP_085981757.1	DUF1391 family protein	-
LJF37_RS06355	1282231..1282752	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF37_RS06360	1283190..1283411	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1272852..1284723	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221853 WP_000813254.1 NZ_CP085815:c1278442-1278287 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221853 NZ_CP117607:c65389-65240 [Escherichia albertii]
ATGACGAAATATACCCTAATTGGGTTGCTCGCCGTGTGTGCCACGGTGTTGTGTTTTTCACTGATATTCAGAGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221853 NZ_CP085815:1278454-1278512 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin