Detailed information of TA system TA221848

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2706731..2706956
• Replicon: chromosome
• Accession: NZ_CP085814
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF38_RS13090
• Protein ID: WP_000813254.1
• Coordinates: 2706801..2706956 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2706731..2706789 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF38_RS13050	2701832..2702053	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF38_RS13055	2702491..2703012	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF38_RS13060	2703120..2703275	-	156	WP_085981757.1	DUF1391 family protein	-
LJF38_RS13065	2703660..2704127	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF38_RS23035	2704309..2704356	+	48	Protein_2536	hypothetical protein	-
LJF38_RS13075	2704400..2704729	+	330	WP_001676916.1	DUF977 family protein	-
LJF38_RS13080	2704891..2705445	-	555	WP_001033796.1	hypothetical protein	-
LJF38_RS13085	2705442..2706374	-	933	WP_000556390.1	hypothetical protein	-
-	2706731..2706789	-	59	-	-	Antitoxin
LJF38_RS13090	2706801..2706956	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF38_RS13095	2707247..2707417	+	171	WP_000734094.1	hypothetical protein	-
LJF38_RS13100	2707480..2708079	+	600	WP_000940751.1	DUF1367 family protein	-
LJF38_RS13105	2708079..2708369	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF38_RS13110	2708366..2708902	+	537	WP_000640113.1	DUF1133 family protein	-
LJF38_RS13115	2711073..2711396	+	324	Protein_2545	tellurite/colicin resistance protein	-
LJF38_RS13120	2711390..2711578	+	189	WP_001688615.1	putative holin	-
LJF38_RS13125	2711568..2711849	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2700520..2712391	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221848 WP_000813254.1 NZ_CP085814:2706801-2706956 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221848 NZ_CP117606:3858284-3858658 [Escherichia albertii]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATTGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCACT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCTAAAAAATACAATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTG
AGACAAGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAATTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTAATCACACCCTATCAACCGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221848 NZ_CP085814:c2706789-2706731 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin